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Lutetium-177-PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial.

1/5 보강

Nature medicine 📖 저널 OA 65% 2022~2026 2025 Vol.31(8) p. 2722-2736

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

환자: mCRPC from the randomized TheraP trial of [¹⁷⁷Lu]Lu-PSMA-617 (n = 97) versus cabazitaxel chemotherapy (n = 83)

I · Intervention 중재 / 시술

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C · Comparison 대조 / 비교

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O · Outcome 결과 / 결론

Our results nominate new candidate biomarkers for [¹⁷⁷Lu]Lu-PSMA-617 selection and ultimately expand the mCRPC predictive biomarker repertoire. We anticipate our ctDNA fraction-aware analytical framework will aid future precision management strategies for [¹⁷⁷Lu]Lu-PSMA-617 and other PSMA-targeted therapeutics.

Kwan EM, Ng SWS, Tolmeijer SH, Emmett L, Sandhu S, Buteau JP

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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