Secular Trends in the Prevalence of Total and Latent Prostate Cancer over Half a Century According to Consecutive Autopsy Cases in a Japanese community: The Hisayama Study.
[BACKGROUND AND OBJECTIVE] Our aim was to investigate secular trends in the period prevalence of total prostate cancer (PC) and latent PC (LPC) according to consecutive autopsy cases in a Japanese com
APA
Taira J, Kawatoko K, et al. (2025). Secular Trends in the Prevalence of Total and Latent Prostate Cancer over Half a Century According to Consecutive Autopsy Cases in a Japanese community: The Hisayama Study.. European urology open science, 78, 9-15. https://doi.org/10.1016/j.euros.2025.05.013
MLA
Taira J, et al.. "Secular Trends in the Prevalence of Total and Latent Prostate Cancer over Half a Century According to Consecutive Autopsy Cases in a Japanese community: The Hisayama Study.." European urology open science, vol. 78, 2025, pp. 9-15.
PMID
40606513
Abstract
[BACKGROUND AND OBJECTIVE] Our aim was to investigate secular trends in the period prevalence of total prostate cancer (PC) and latent PC (LPC) according to consecutive autopsy cases in a Japanese community.
[METHODS] A total of 1355 deceased men aged >40 yr in a Japanese community underwent consecutive autopsy examination between 1962 and 2020. The period prevalence of total PC and of LPC was calculated for 15-yr intervals, and secular trends were analyzed using a logistic regression model.
[KEY FINDINGS AND LIMITATIONS] The period prevalence of both total PC (from 1.7% in 1962-1976 to 19% in 2007-2020; < 0.001) and LPC (from 1.3% in 1962-1976 to 11% in 2007-2020; < 0.001) significantly increased over time ( < 0.001). The age-specific period prevalence of total PC also increased for the age groups 60-79 yr (from 0.55% in 1962-1976 to 9.8% in 2007-2020; = 0.005) and ≥80 yr (from 6.5% in 1962-1976 to 26% in 2007-2020; = 0.003). There was no evidence of a secular change in the pathology of LPC.
[CONCLUSIONS AND CLINICAL IMPLICATIONS] The period prevalence of autopsy-proven total PC and LPC increased over the past 60 yr in a Japanese community. It is likely that this upward trend has involved additional factors beyond improvements in screening and diagnostic techniques or the aging of the population.
[PATIENT SUMMARY] We used data from autopsy examinations in a Japanese population to analyze long-term trends for the occurrence of prostate cancer. We found a significant rise in the occurrence of both diagnosed prostate cancer and latent prostate cancer over the past 60 years in this Japanese community.
[METHODS] A total of 1355 deceased men aged >40 yr in a Japanese community underwent consecutive autopsy examination between 1962 and 2020. The period prevalence of total PC and of LPC was calculated for 15-yr intervals, and secular trends were analyzed using a logistic regression model.
[KEY FINDINGS AND LIMITATIONS] The period prevalence of both total PC (from 1.7% in 1962-1976 to 19% in 2007-2020; < 0.001) and LPC (from 1.3% in 1962-1976 to 11% in 2007-2020; < 0.001) significantly increased over time ( < 0.001). The age-specific period prevalence of total PC also increased for the age groups 60-79 yr (from 0.55% in 1962-1976 to 9.8% in 2007-2020; = 0.005) and ≥80 yr (from 6.5% in 1962-1976 to 26% in 2007-2020; = 0.003). There was no evidence of a secular change in the pathology of LPC.
[CONCLUSIONS AND CLINICAL IMPLICATIONS] The period prevalence of autopsy-proven total PC and LPC increased over the past 60 yr in a Japanese community. It is likely that this upward trend has involved additional factors beyond improvements in screening and diagnostic techniques or the aging of the population.
[PATIENT SUMMARY] We used data from autopsy examinations in a Japanese population to analyze long-term trends for the occurrence of prostate cancer. We found a significant rise in the occurrence of both diagnosed prostate cancer and latent prostate cancer over the past 60 years in this Japanese community.