mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression.
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Sublethal apoptotic stress causing the permeabilization of some mitochondria coupled with cytosolic mitochondrial DNA (mtDNA) accumulation is known to promote cellular senescence.
APA
Cañadas I, Murayama T, Galluzzi L (2025). mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression.. Trends in cancer, 11(8), 716-718. https://doi.org/10.1016/j.trecan.2025.06.010
MLA
Cañadas I, et al.. "mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression.." Trends in cancer, vol. 11, no. 8, 2025, pp. 716-718.
PMID
40610348 ↗
Abstract 한글 요약
Sublethal apoptotic stress causing the permeabilization of some mitochondria coupled with cytosolic mitochondrial DNA (mtDNA) accumulation is known to promote cellular senescence. Lai et al. have recently demonstrated that this may be accompanied by mtDNA release within extracellular vesicles that promote local immunosuppression via myeloid-derived suppressor cells.
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