Primary Score as a Predictive Marker in Intermediate-Risk Prostate Cancer: Insights from PSMA PET/CT Imaging.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: intermediate-risk prostate cancer (PCa)
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] These results highlight the predictive value of the PRIMARY score for Gleason score changes. [SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1007/s13139-025-00920-6.
[PURPOSE] This study aimed to determine whether the PRIMARY Score on prostate specific membrane antigen (PSMA) positron emission tomography/compute tomography (PET/CT) can predict adverse pathology an
- 표본수 (n) 50
APA
Evangelista L, Muraglia L, et al. (2025). Primary Score as a Predictive Marker in Intermediate-Risk Prostate Cancer: Insights from PSMA PET/CT Imaging.. Nuclear medicine and molecular imaging, 59(4), 255-260. https://doi.org/10.1007/s13139-025-00920-6
MLA
Evangelista L, et al.. "Primary Score as a Predictive Marker in Intermediate-Risk Prostate Cancer: Insights from PSMA PET/CT Imaging.." Nuclear medicine and molecular imaging, vol. 59, no. 4, 2025, pp. 255-260.
PMID
40686831 ↗
Abstract 한글 요약
[PURPOSE] This study aimed to determine whether the PRIMARY Score on prostate specific membrane antigen (PSMA) positron emission tomography/compute tomography (PET/CT) can predict adverse pathology and prognosis in patients with intermediate-risk prostate cancer (PCa).
[MATERIALS AND METHODS] This is a retrospective, multicenter analysis of patients diagnosed with intermediate risk PCa. Patients were staged using pelvic multiparametric magnetic resonance imaging (mpMRI) and radiolabeled PSMA PET/CT, either [68 Ga]Ga-PSMA-11 or [18F]F-PSMA1007, to evaluate the extent of disease before initiating appropriate treatment. PI-RADS Version 2.1 and PRIMARY score were used for a quantitative analysis, respectively for mpMRI and PSMA PET/CT. Biochemical recurrence of disease was defined as a post-operative serum PSA > 0.2 ng/ml on two separate occasions at minimum 2-week intervals.
[RESULTS] Seventy-eight intermediate-risk PCa patients were enrolled. PRIMARY scores > 3 was found in 62% of favorable (n = 50) and 71% of unfavorable cases (n = 28). Gleason score changes occurred in 20% of favorable-risk patients, with 90% having a PRIMARY score > 3. Biochemical recurrence was observed in 17% of patients during follow-up, predominantly among favorable-risk cases (13%), where most had Gleason score changes and a PRIMARY score > 3.
[CONCLUSIONS] These results highlight the predictive value of the PRIMARY score for Gleason score changes.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1007/s13139-025-00920-6.
[MATERIALS AND METHODS] This is a retrospective, multicenter analysis of patients diagnosed with intermediate risk PCa. Patients were staged using pelvic multiparametric magnetic resonance imaging (mpMRI) and radiolabeled PSMA PET/CT, either [68 Ga]Ga-PSMA-11 or [18F]F-PSMA1007, to evaluate the extent of disease before initiating appropriate treatment. PI-RADS Version 2.1 and PRIMARY score were used for a quantitative analysis, respectively for mpMRI and PSMA PET/CT. Biochemical recurrence of disease was defined as a post-operative serum PSA > 0.2 ng/ml on two separate occasions at minimum 2-week intervals.
[RESULTS] Seventy-eight intermediate-risk PCa patients were enrolled. PRIMARY scores > 3 was found in 62% of favorable (n = 50) and 71% of unfavorable cases (n = 28). Gleason score changes occurred in 20% of favorable-risk patients, with 90% having a PRIMARY score > 3. Biochemical recurrence was observed in 17% of patients during follow-up, predominantly among favorable-risk cases (13%), where most had Gleason score changes and a PRIMARY score > 3.
[CONCLUSIONS] These results highlight the predictive value of the PRIMARY score for Gleason score changes.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1007/s13139-025-00920-6.
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