Cytotoxic effects of amentoflavone from on HCT-116, SNB-19, and pC-3 cells with structural insights from molecular docking.
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Amentoflavone, a biflavonoid found in plants of the Ochnaceae family, was studied for its potential in treating colorectal, glioblastoma, and prostate cancer experimental models.
APA
Frota LS, Pessoa CDÓ, et al. (2025). Cytotoxic effects of amentoflavone from on HCT-116, SNB-19, and pC-3 cells with structural insights from molecular docking.. Natural product research, 1-9. https://doi.org/10.1080/14786419.2025.2545972
MLA
Frota LS, et al.. "Cytotoxic effects of amentoflavone from on HCT-116, SNB-19, and pC-3 cells with structural insights from molecular docking.." Natural product research, 2025, pp. 1-9.
PMID
40794464 ↗
Abstract 한글 요약
Amentoflavone, a biflavonoid found in plants of the Ochnaceae family, was studied for its potential in treating colorectal, glioblastoma, and prostate cancer experimental models. Tests on human tumour cells HCT-116, SNB-19, and PC-3 showed significant inhibition of cell proliferation by amentoflavone, notably 95.60% inhibition and an IC of 0.675 ± 0.26 µM in HCT-116 cells. Computational studies indicated that amentoflavone interacts significantly with the active site of the CDK2 protein, comparable to the inhibitor kenpaullone, a reference compound in oncology research. Furthermore, agathisflavone an isomer of amentoflavone, exhibited the strongest interaction with CDK2 protein, with a binding energy of -10.3 kcal/mol, being very close to the positive control sorafenib (-10.6 kcal/mol). These findings underscore the therapeutic potential of amentoflavone and the ongoing importance of researching natural compounds for cancer treatment.
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