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PSMA-Uptake Reveals Globet Cell Cancer of the Appendix in a Patient Staged for Prostate Cancer With PET/CT.

Clinical nuclear medicine 2025 Vol.50(9) p. 861-862

Lampe NA, Anzic N, Stürmlin J, Strobel K, Grünig H

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18 F-PSMA 1007 is an established tracer for staging intermediate and high-risk prostate cancer.

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APA Lampe NA, Anzic N, et al. (2025). PSMA-Uptake Reveals Globet Cell Cancer of the Appendix in a Patient Staged for Prostate Cancer With PET/CT.. Clinical nuclear medicine, 50(9), 861-862. https://doi.org/10.1097/RLU.0000000000005832
MLA Lampe NA, et al.. "PSMA-Uptake Reveals Globet Cell Cancer of the Appendix in a Patient Staged for Prostate Cancer With PET/CT.." Clinical nuclear medicine, vol. 50, no. 9, 2025, pp. 861-862.
PMID 40094600

Abstract

18 F-PSMA 1007 is an established tracer for staging intermediate and high-risk prostate cancer. Besides prostate cancer cells, benign tumors and inflammations/infections can show unspecific PSMA uptake. We present a case of incidental PSMA uptake of the appendix revealing a globet cell adenocarcinoma in histology after surgical resection. Globet cell tumors are rare neoplasms of the appendix. Patients with incidental PSMA uptake in the appendix should undergo further work-up.

MeSH Terms

Humans; Male; Adenocarcinoma; Antigens, Surface; Appendiceal Neoplasms; Biological Transport; Glutamate Carboxypeptidase II; Neoplasm Staging; Oligopeptides; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Niacinamide