Protocol for covalent-targeted and activatable photoacoustic imaging agent for tumor imaging in mice.
Activatable photoacoustic imaging probes offer a strategy to efficiently reduce background noise from endogenous chromophores.
APA
Song J, Zhai T, et al. (2025). Protocol for covalent-targeted and activatable photoacoustic imaging agent for tumor imaging in mice.. STAR protocols, 6(3), 104046. https://doi.org/10.1016/j.xpro.2025.104046
MLA
Song J, et al.. "Protocol for covalent-targeted and activatable photoacoustic imaging agent for tumor imaging in mice.." STAR protocols, vol. 6, no. 3, 2025, pp. 104046.
PMID
40849913
Abstract
Activatable photoacoustic imaging probes offer a strategy to efficiently reduce background noise from endogenous chromophores. We present a protocol for tumor imaging in mice using an activatable covalent photoacoustic imaging probe, NOx-JS013. We describe steps for synthesizing NOx-JS013, in vitro and in situ validation through gel-based activity-based protein profiling and cellular imaging, and tumor imaging of aggressive prostate cancer mouse models. This approach provides a strategy for mitigating background noise in the development of photoacoustic imaging probes. For complete details on the use and execution of this protocol, please refer to Song et al..
MeSH Terms
Photoacoustic Techniques; Animals; Mice; Male; Prostatic Neoplasms; Neoplasms; Neoplasms, Experimental; Humans; Cell Line, Tumor; Molecular Probes; Sterol Esterase; Disease Models, Animal
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