Altered Glycosylation of PSA in Prostate Cancer Tissue.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
162 patients, PSA-glycoforms detected by succinylated wheat germ (WGA) and Vicia villosa (VVA) lectins were enriched in cancerous tissues as compared to adjacent benign tissues from the same patients (p < 10 for both, Kruskal-Wallis H test), although strong total PSA staining was more often found in benign tissues (p = 6*10).
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
we showed that glycosylation of PSA in cancerous tissues is different from that in benign prostate.
[BACKGROUND] The glycosylation of proteins is commonly altered in cancer.
APA
Koistinen H, Merivirta RM, et al. (2025). Altered Glycosylation of PSA in Prostate Cancer Tissue.. The Prostate, 85(14), 1290-1298. https://doi.org/10.1002/pros.70014
MLA
Koistinen H, et al.. "Altered Glycosylation of PSA in Prostate Cancer Tissue.." The Prostate, vol. 85, no. 14, 2025, pp. 1290-1298.
PMID
40635354 ↗
Abstract 한글 요약
[BACKGROUND] The glycosylation of proteins is commonly altered in cancer. This offers novel opportunities for cancer biomarker development. As prostate-specific antigen (PSA) is a glycoprotein, identification of cancer-specific PSA-glycoforms is feasible. Such PSA-glycoforms may provide valuable diagnostic and prognostic information.
[METHODS] PSA-glycoforms were studied in tissues, using in situ proximity-ligation assay (PLA)-based detection with a PSA-specific antibody and 25 different glycan-binding lectins.
[RESULTS] Using 25 different lectins and a small tissue microarray (TMA), we showed that glycosylation of PSA in cancerous tissues is different from that in benign prostate. In a larger TMA with samples from 162 patients, PSA-glycoforms detected by succinylated wheat germ (WGA) and Vicia villosa (VVA) lectins were enriched in cancerous tissues as compared to adjacent benign tissues from the same patients (p < 10 for both, Kruskal-Wallis H test), although strong total PSA staining was more often found in benign tissues (p = 6*10).
[CONCLUSIONS] We showed here that glycosylation of PSA is changed in situ in prostate cancer. The identified lectins, showing preferential binding to cancer-associated PSA-glycoforms, will aid the future development of a diagnostic serum test of prostate cancer. Such a test has potential to revolutionize prostate cancer diagnostics.
[METHODS] PSA-glycoforms were studied in tissues, using in situ proximity-ligation assay (PLA)-based detection with a PSA-specific antibody and 25 different glycan-binding lectins.
[RESULTS] Using 25 different lectins and a small tissue microarray (TMA), we showed that glycosylation of PSA in cancerous tissues is different from that in benign prostate. In a larger TMA with samples from 162 patients, PSA-glycoforms detected by succinylated wheat germ (WGA) and Vicia villosa (VVA) lectins were enriched in cancerous tissues as compared to adjacent benign tissues from the same patients (p < 10 for both, Kruskal-Wallis H test), although strong total PSA staining was more often found in benign tissues (p = 6*10).
[CONCLUSIONS] We showed here that glycosylation of PSA is changed in situ in prostate cancer. The identified lectins, showing preferential binding to cancer-associated PSA-glycoforms, will aid the future development of a diagnostic serum test of prostate cancer. Such a test has potential to revolutionize prostate cancer diagnostics.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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