The Clock and the Scalpel: Does delayed Robot-assisted radical prostatectomy affect pathological progression and upgrading in prostate cancer?
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
RARP between 2011 and 2022 were retrospectively reviewed
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] Although delayed RARP did not compromise adverse pathological outcomes, it was a risk factor for GG upgrading, particularly beyond 6 months. Thus, prolonged delays should be approached with appropriate monitoring.
[INTRODUCTION] We investigated whether surgical delay may be associated with histological progression in patients treated with robotic-assisted radical prostatectomy (RARP) for prostate cancer (PCa).
- 95% CI 0.85-1.06
- OR 0.95
APA
Koterazawa S, Goto T, et al. (2025). The Clock and the Scalpel: Does delayed Robot-assisted radical prostatectomy affect pathological progression and upgrading in prostate cancer?. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 51(10), 110357. https://doi.org/10.1016/j.ejso.2025.110357
MLA
Koterazawa S, et al.. "The Clock and the Scalpel: Does delayed Robot-assisted radical prostatectomy affect pathological progression and upgrading in prostate cancer?." European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 51, no. 10, 2025, pp. 110357.
PMID
40834695 ↗
Abstract 한글 요약
[INTRODUCTION] We investigated whether surgical delay may be associated with histological progression in patients treated with robotic-assisted radical prostatectomy (RARP) for prostate cancer (PCa).
[MATERIALS AND METHODS] Patients diagnosed with localized (cT1-2cN0cM0) PCa who underwent RARP between 2011 and 2022 were retrospectively reviewed. Surgical delay was categorized into four groups based on the time from biopsy to RARP: 0-3, 4-6, 7-12, and >12 months. The primary outcome was adverse pathological outcomes (pT3-T4 disease, lymph node invasion, or positive surgical margin). The secondary outcome was Gleason grade group (GG) upgrading.
[RESULTS] A total of 2362 (39.3 %) patients underwent RARP within 0-3 months after biopsy, 3045 (50.6 %) within 4-6 months, 454 (7.5 %) within 7-12 months, and 154 (2.6 %) after more than 12 months. Patients who underwent RARP within 4-6 months (OR = 0.95, 95 % CI 0.85-1.06), 7-12 months (OR = 0.91, 95 % CI 0.76-1.12), and >12 months (OR = 1.04, 95 % CI 0.73-1.47) did not have significantly increased odds of adverse pathological outcomes than those undergoing surgery within 0-3 months. Subgroup analyses for the low-to-intermediate-risk and high-risk groups showed no significant differences in adverse pathology outcomes. However, surgical delays >6 months were significantly associated with increased likelihood of GG upgrading.
[CONCLUSION] Although delayed RARP did not compromise adverse pathological outcomes, it was a risk factor for GG upgrading, particularly beyond 6 months. Thus, prolonged delays should be approached with appropriate monitoring.
[MATERIALS AND METHODS] Patients diagnosed with localized (cT1-2cN0cM0) PCa who underwent RARP between 2011 and 2022 were retrospectively reviewed. Surgical delay was categorized into four groups based on the time from biopsy to RARP: 0-3, 4-6, 7-12, and >12 months. The primary outcome was adverse pathological outcomes (pT3-T4 disease, lymph node invasion, or positive surgical margin). The secondary outcome was Gleason grade group (GG) upgrading.
[RESULTS] A total of 2362 (39.3 %) patients underwent RARP within 0-3 months after biopsy, 3045 (50.6 %) within 4-6 months, 454 (7.5 %) within 7-12 months, and 154 (2.6 %) after more than 12 months. Patients who underwent RARP within 4-6 months (OR = 0.95, 95 % CI 0.85-1.06), 7-12 months (OR = 0.91, 95 % CI 0.76-1.12), and >12 months (OR = 1.04, 95 % CI 0.73-1.47) did not have significantly increased odds of adverse pathological outcomes than those undergoing surgery within 0-3 months. Subgroup analyses for the low-to-intermediate-risk and high-risk groups showed no significant differences in adverse pathology outcomes. However, surgical delays >6 months were significantly associated with increased likelihood of GG upgrading.
[CONCLUSION] Although delayed RARP did not compromise adverse pathological outcomes, it was a risk factor for GG upgrading, particularly beyond 6 months. Thus, prolonged delays should be approached with appropriate monitoring.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Retrospective Studies
- Time-to-Treatment
- Neoplasm Grading
- Prostatic Neoplasms
- Prostatectomy
- Disease Progression
- Robotic Surgical Procedures
- Prostate
- Biopsy
- Time Factors
- Treatment Outcome
- Risk Factors
- Treatment Delay
- Neoplasm Staging
- Humans
- Male
- Aged
- Margins of Excision
- Neoplasm Invasiveness
- Grade group upgrading
- Lymph node invasion
- Positive surgical margin
- Surgical delay
- pT3–T4 disease
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