Investigation of the association of tRNA-derived fragments (tRF-17-79MP9PP and tRF-18-79MP9P04) with prostate cancer.
1/5 보강
[INTRODUCTION] This study investigates the association between the levels of two tRNA-derived fragments, tRF-17-79MP9PP and tRF-18-79MP9P04, and the pathophysiology of prostate cancer (PCa).
- p-value p < 0.001
APA
Ergun S, Önem K, et al. (2025). Investigation of the association of tRNA-derived fragments (tRF-17-79MP9PP and tRF-18-79MP9P04) with prostate cancer.. Molecular biology reports, 53(1), 6. https://doi.org/10.1007/s11033-025-11176-w
MLA
Ergun S, et al.. "Investigation of the association of tRNA-derived fragments (tRF-17-79MP9PP and tRF-18-79MP9P04) with prostate cancer.." Molecular biology reports, vol. 53, no. 1, 2025, pp. 6.
PMID
41129034 ↗
Abstract 한글 요약
[INTRODUCTION] This study investigates the association between the levels of two tRNA-derived fragments, tRF-17-79MP9PP and tRF-18-79MP9P04, and the pathophysiology of prostate cancer (PCa).
[MATERIALS AND METHODS] Forty patients were included: 8 with benign prostatic hyperplasia (BPH) and 32 with different PCa grades. Total RNA was extracted from formalin-fixed paraffin-embedded (FFPE) tumor tissues, and the levels of tRF-17-79MP9PP and tRF-18-79MP9P04 were analyzed.
[RESULTS] The abundance of tRF-17-79MP9PP increased progressively with cancer grade (p < 0.001), with the highest levels observed in advanced PCa. Interestingly, BPH also showed higher tRF-17-79MP9PP level than low- and mild-grade PCa. Level of tRF-18-79MP9P04 was comparable between BPH and low-grade PCa, but significantly higher in mild, high, and advanced grades (p < 0.001). Furthermore, PSA levels were significantly correlated with both tRF-17-79MP9PP and tRF-18-79MP9P04 in PCa patients (p < 0.001), but not in the BPH group.
[DISCUSSION] Both tRF-17-79MP9PP and tRF-18-79MP9P04 appear to play important roles in prostate cancer, demonstrating potential oncogenic behavior in advanced stages, which contrasts with previous studies reporting tumor-suppressive effects.
[CONCLUSION] These findings indicate that elevated levels of these tRNA-derived fragments may serve as potential biomarkers for distinguishing between different grades of PCa.
[MATERIALS AND METHODS] Forty patients were included: 8 with benign prostatic hyperplasia (BPH) and 32 with different PCa grades. Total RNA was extracted from formalin-fixed paraffin-embedded (FFPE) tumor tissues, and the levels of tRF-17-79MP9PP and tRF-18-79MP9P04 were analyzed.
[RESULTS] The abundance of tRF-17-79MP9PP increased progressively with cancer grade (p < 0.001), with the highest levels observed in advanced PCa. Interestingly, BPH also showed higher tRF-17-79MP9PP level than low- and mild-grade PCa. Level of tRF-18-79MP9P04 was comparable between BPH and low-grade PCa, but significantly higher in mild, high, and advanced grades (p < 0.001). Furthermore, PSA levels were significantly correlated with both tRF-17-79MP9PP and tRF-18-79MP9P04 in PCa patients (p < 0.001), but not in the BPH group.
[DISCUSSION] Both tRF-17-79MP9PP and tRF-18-79MP9P04 appear to play important roles in prostate cancer, demonstrating potential oncogenic behavior in advanced stages, which contrasts with previous studies reporting tumor-suppressive effects.
[CONCLUSION] These findings indicate that elevated levels of these tRNA-derived fragments may serve as potential biomarkers for distinguishing between different grades of PCa.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
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