NPRL2 gene expression as a predictor of biochemical recurrence after robot-assisted radical prostatectomy.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
RARP performed by three different surgeons
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
These findings suggest a potential prognostic value of NPRL2; however, further validation studies are needed due to the small sample size and the subjective nature of the assessment. [CLINICAL TRIAL NUMBER] Not applicable.
[OBJECTIVE] This study aimed to investigate the potential prognostic role of nitrogen permease regulator-like 2 (NPRL2) gene expression in predicting biochemical recurrence (BCR) following robot-assis
- p-value p = 0.011
- p-value p = 0.009
- 95% CI 1.38-12.20
- OR 4.10
APA
Yahsi S, Öksüz P, et al. (2025). NPRL2 gene expression as a predictor of biochemical recurrence after robot-assisted radical prostatectomy.. BMC urology, 25(1), 275. https://doi.org/10.1186/s12894-025-01820-9
MLA
Yahsi S, et al.. "NPRL2 gene expression as a predictor of biochemical recurrence after robot-assisted radical prostatectomy.." BMC urology, vol. 25, no. 1, 2025, pp. 275.
PMID
41185006 ↗
Abstract 한글 요약
[OBJECTIVE] This study aimed to investigate the potential prognostic role of nitrogen permease regulator-like 2 (NPRL2) gene expression in predicting biochemical recurrence (BCR) following robot-assisted radical prostatectomy (RARP).
[MATERIALS AND METHODS] This single-center retrospective study included patients who underwent RARP performed by three different surgeons. Clinicopathological data and NPRL2 expression in tumor tissues were evaluated immunohistochemically (IHC). The level of NPRL2 staining was quantitatively assessed using an IHC score based on staining intensity. Factors associated with BCR were analyzed using multivariable logistic regression.
[RESULTS] A preoperative PSA level > 10 ng/mL (OR: 4.10, 95% CI: 1.38-12.20, p = 0.011), an International Society of Urological Pathology (ISUP) grade group > 3 (OR: 4.39, 95% CI: 1.45-13.29, p = 0.009), and high NPRL2 expression (IHC score > 4) (OR: 3.82, 95% CI: 1.07-13.62, p = 0.039) were identified as independent risk factors for BCR.
[CONCLUSION] High NPRL2 expression is associated with an increased risk of BCR following RARP. These findings suggest a potential prognostic value of NPRL2; however, further validation studies are needed due to the small sample size and the subjective nature of the assessment.
[CLINICAL TRIAL NUMBER] Not applicable.
[MATERIALS AND METHODS] This single-center retrospective study included patients who underwent RARP performed by three different surgeons. Clinicopathological data and NPRL2 expression in tumor tissues were evaluated immunohistochemically (IHC). The level of NPRL2 staining was quantitatively assessed using an IHC score based on staining intensity. Factors associated with BCR were analyzed using multivariable logistic regression.
[RESULTS] A preoperative PSA level > 10 ng/mL (OR: 4.10, 95% CI: 1.38-12.20, p = 0.011), an International Society of Urological Pathology (ISUP) grade group > 3 (OR: 4.39, 95% CI: 1.45-13.29, p = 0.009), and high NPRL2 expression (IHC score > 4) (OR: 3.82, 95% CI: 1.07-13.62, p = 0.039) were identified as independent risk factors for BCR.
[CONCLUSION] High NPRL2 expression is associated with an increased risk of BCR following RARP. These findings suggest a potential prognostic value of NPRL2; however, further validation studies are needed due to the small sample size and the subjective nature of the assessment.
[CLINICAL TRIAL NUMBER] Not applicable.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Male
- Humans
- Prostatectomy
- Middle Aged
- Prostatic Neoplasms
- Retrospective Studies
- Robotic Surgical Procedures
- Neoplasm Recurrence
- Local
- Aged
- Predictive Value of Tests
- Prognosis
- Gene Expression
- Prostate-Specific Antigen
- Biomarkers
- Tumor
- Gene Expression Regulation
- Neoplastic
- Biochemical recurrence
- NPRL2 gene expression
- Prostate cancer
- Robot-assisted radical prostatectomy
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