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BrUOG360: A Phase Ib/II Study of Copanlisib in Combination with Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC).

1/5 보강

Cancer research communications 📖 저널 OA 93.2% 2023~2026 2025 Vol.5(12) p. 2142-2148

PICO 자동 추출 (휴리스틱, conf 3/4)

유사 논문

P · Population 대상 환자/모집단

환자: or without alterations in HR repair pathway genes

I · Intervention 중재 / 시술

taxanes, and one patient received PARPi

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

Based on preclinical studies, the inhibition of PI3K disrupts HR, and PARP blockade induces AKT activation, supporting the combination of PI3Ki and PARPi. Herein, we investigated the safety and preliminary efficacy of the PI3Ki copanlisib and the PARPi rucaparib in patients with or without alterations in HR repair pathway genes.

De Souza AL, Hadfield MJ, Lu S, Golijanin DJ, Wood R, Margolis J

📖 무료 전문 🟢 PMC 전문 PMC12690636

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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