siRNA-based Nanocarriers for Targeted Therapy in Prostate Cancer: Implications for Male Fertility Preservation.
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Prostate cancer (PC), a significant global health burden, is further complicated by therapeutic resistance, systemic toxicity, and adverse effects on male fertility associated with conventional treatm
APA
Jangde KK, Sharma R, et al. (2025). siRNA-based Nanocarriers for Targeted Therapy in Prostate Cancer: Implications for Male Fertility Preservation.. Drug discovery today, 30(12), 104543. https://doi.org/10.1016/j.drudis.2025.104543
MLA
Jangde KK, et al.. "siRNA-based Nanocarriers for Targeted Therapy in Prostate Cancer: Implications for Male Fertility Preservation.." Drug discovery today, vol. 30, no. 12, 2025, pp. 104543.
PMID
41241375 ↗
Abstract 한글 요약
Prostate cancer (PC), a significant global health burden, is further complicated by therapeutic resistance, systemic toxicity, and adverse effects on male fertility associated with conventional treatments. Small interfering RNA (siRNA)-based therapeutics offer molecular precision in oncogene silencing and tumor-promoting pathways. However, their clinical translation is constrained by challenges related to stability, delivery, and cellular uptake. Nanocarriers, including lipid-based, exosome-based, and other polymeric-based systems, could enhance stability, specificity, and efficacy. In this review, we highlight biomarker-targeted siRNA codelivery for PC, considering reproductive health and translational barriers, highlighting the future of fertility-preserving and quality of life-oriented therapies.
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