Advancing 3D scaffold models for metastatic prostate cancer in bone: Materials, manufacture, and future perspectives.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
This variability is likely driven by the lack of standardisation and guidance.
I · Intervention 중재 / 시술
little research attention
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
freeze drying) to more advanced additive manufacturing strategies that enable the production of more intricate and controlled structures. Ultimately, we provide insights and future directions to guide researchers investigating this poorly studied field.
The metastatic spread of prostate cancer to the bone is debilitating for patients and is associated with a poor prognostic outlook.
APA
Dozzo A, Dedeloudi A, et al. (2025). Advancing 3D scaffold models for metastatic prostate cancer in bone: Materials, manufacture, and future perspectives.. Biomaterials and biosystems, 20, 100125. https://doi.org/10.1016/j.bbiosy.2025.100125
MLA
Dozzo A, et al.. "Advancing 3D scaffold models for metastatic prostate cancer in bone: Materials, manufacture, and future perspectives.." Biomaterials and biosystems, vol. 20, 2025, pp. 100125.
PMID
41399483 ↗
Abstract 한글 요약
The metastatic spread of prostate cancer to the bone is debilitating for patients and is associated with a poor prognostic outlook. Gaining a deeper insight into the pathophysiology of prostate cancer and its metastatic spread using advanced, in vitro, 3D models could enhance disease understanding and the successful development of new drug treatments. The in vitro replication of prostate cancer metastasisation to bone is challenging and has received little research attention. The 3D scaffold models investigated to date exhibit different physical characteristics and utilise a diverse range of materials, and manufacturing methods. This variability is likely driven by the lack of standardisation and guidance. Herein, we review the scaffold models used as in vitro bone niches of prostate cancer metastases and examine the different physical (e.g. porosity, pore geometry) and material criteria that guide the design and production of artificial 3D bone aliases. We critically review different manufacturing techniques ranging from standard techniques (e.g. freeze drying) to more advanced additive manufacturing strategies that enable the production of more intricate and controlled structures. Ultimately, we provide insights and future directions to guide researchers investigating this poorly studied field.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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