Synthesis of the Abiraterone Derivatives 5α- and 5β-Δ-Abiraterone and Structural Determination of an Unknown Metabolite in Human Serum Derived from Oral Abiraterone Acetate.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: prostate cancer
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The metabolic pathway may have formed 5β-D1A rather than 5α-D1A because of the higher activity of steroid 5β-reductase compared with that of 5α-reductase. These findings are expected to lead to the discovery of new metabolic pathways.
Abiraterone (Abi) acetate, an anticancer drug, produces metabolites in the serum of patients with prostate cancer.
APA
Hayama N, Horiyama S, et al. (2025). Synthesis of the Abiraterone Derivatives 5α- and 5β-Δ-Abiraterone and Structural Determination of an Unknown Metabolite in Human Serum Derived from Oral Abiraterone Acetate.. Chembiochem : a European journal of chemical biology, 26(24), e202500675. https://doi.org/10.1002/cbic.202500675
MLA
Hayama N, et al.. "Synthesis of the Abiraterone Derivatives 5α- and 5β-Δ-Abiraterone and Structural Determination of an Unknown Metabolite in Human Serum Derived from Oral Abiraterone Acetate.." Chembiochem : a European journal of chemical biology, vol. 26, no. 24, 2025, pp. e202500675.
PMID
41251091 ↗
Abstract 한글 요약
Abiraterone (Abi) acetate, an anticancer drug, produces metabolites in the serum of patients with prostate cancer. Three unknown metabolites of Abi are previously discovered and the structures of two of these compounds are determined by comparing their LC-based retention times with those of synthesized compounds. However, the structure of the third metabolite is not identified. Herein, two new Abi derivatives, 5α-Δ-abiraterone (5α-D1A) and 5β-Δ-abiraterone (5β-D1A), with a molecular weight of 348, are successfully synthesized as candidates for the third unknown metabolite. 5β-D1A is confirmed as this third metabolite based on its retention time in the extracted ion chromatogram. The metabolic pathway may have formed 5β-D1A rather than 5α-D1A because of the higher activity of steroid 5β-reductase compared with that of 5α-reductase. These findings are expected to lead to the discovery of new metabolic pathways.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.