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68 Ga-PSMA PET/CT Identifies "Pseudo-progression" of Bone Lesions in Prostate Cancer Observed on 68 Ga-DOTA-IBA PET/CT.

Clinical nuclear medicine 2026 Vol.51(1) p. 87-89

Huang D, Zhang N, Pang S, Gong J, Chen Y

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We report a case where 68 Ga-PSMA PET/CT distinguished "pseudo-progression" from progression observed on 68 Ga-DOTA-IBA PET/CT.

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BibTeX ↓ RIS ↓
APA Huang D, Zhang N, et al. (2026). 68 Ga-PSMA PET/CT Identifies "Pseudo-progression" of Bone Lesions in Prostate Cancer Observed on 68 Ga-DOTA-IBA PET/CT.. Clinical nuclear medicine, 51(1), 87-89. https://doi.org/10.1097/RLU.0000000000006085
MLA Huang D, et al.. "68 Ga-PSMA PET/CT Identifies "Pseudo-progression" of Bone Lesions in Prostate Cancer Observed on 68 Ga-DOTA-IBA PET/CT.." Clinical nuclear medicine, vol. 51, no. 1, 2026, pp. 87-89.
PMID 40762993
DOI 10.1097/RLU.0000000000006085

Abstract

We report a case where 68 Ga-PSMA PET/CT distinguished "pseudo-progression" from progression observed on 68 Ga-DOTA-IBA PET/CT. In a 75-year-old man with metastatic castration-resistant prostate cancer (mCRPC), 68 Ga-DOTA-IBA PET/CT revealed markedly increased tracer uptake in bone metastases compared with pretreatment imaging, suggesting radiologic progression. However, 68 Ga-PSMA-11 PET/CT images demonstrated the complete metabolic response (PERCIST 1.0), revealing "pseudo-progression" of bone lesions in 68 Ga-DOTA-IBA, especially when combined with clinical symptoms, PSA, and ALP levels.

MeSH Terms

Humans; Male; Aged; Positron Emission Tomography Computed Tomography; Bone Neoplasms; Prostatic Neoplasms; Disease Progression; Gallium Radioisotopes; Edetic Acid; Organometallic Compounds; Gallium Isotopes

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