Impact of Androgen Deprivation Therapy on Choroidal Microcirculation Assessed Using Laser Speckle Flowgraphy.
[OBJECTIVE] To determine whether androgen deprivation therapy (ADT) alters laser speckle flowgraphy (LSFG)-detectable choroidal microvascular dynamics: mean blur rate (MBR, blood flow) and beat streng
- p-value p < 0.001
- p-value p = 0.028
APA
Hashimoto R, Oka R, et al. (2026). Impact of Androgen Deprivation Therapy on Choroidal Microcirculation Assessed Using Laser Speckle Flowgraphy.. Microcirculation (New York, N.Y. : 1994), 33(1), e70048. https://doi.org/10.1111/micc.70048
MLA
Hashimoto R, et al.. "Impact of Androgen Deprivation Therapy on Choroidal Microcirculation Assessed Using Laser Speckle Flowgraphy.." Microcirculation (New York, N.Y. : 1994), vol. 33, no. 1, 2026, pp. e70048.
PMID
41467647
Abstract
[OBJECTIVE] To determine whether androgen deprivation therapy (ADT) alters laser speckle flowgraphy (LSFG)-detectable choroidal microvascular dynamics: mean blur rate (MBR, blood flow) and beat strength over MBR (BOM, microvascular resistance). We also investigated whether such changes emerge even when cardio-ankle vascular index (CAVI)-assessed large-artery stiffness remains unchanged.
[METHODS] This study included 17 right eyes of 17 men with prostate cancer. Serum testosterone, CAVI, and choroidal parameters (MBR, BOM) were obtained at baseline and 6 months post-ADT. Central choroidal thickness (CCT) and ocular perfusion pressure (OPP) were also recorded.
[RESULTS] Serum testosterone significantly decreased (4.45 ± 1.96 to 0.20 ± 0.08 ng/mL; p < 0.001) after 6 months. Choroidal BOM increased significantly (0.94 ± 0.31 to 1.11 ± 0.31; p = 0.028), whereas CAVI (10.70 ± 1.28 to 10.68 ± 1.19), choroidal MBR (8.46 ± 4.50 to 7.89 ± 3.48), CCT, and OPP did not change significantly.
[CONCLUSION] Choroidal BOM increased significantly during the initial 6 months of ADT, indicating higher microvascular resistance despite stable choroidal blood flow and unchanged large artery stiffness. This supports a "microcirculation-first" model. LSFG-derived BOM may serve as a biomarker for early detection and monitoring of microcirculatory dysfunction under systemic testosterone suppression.
[METHODS] This study included 17 right eyes of 17 men with prostate cancer. Serum testosterone, CAVI, and choroidal parameters (MBR, BOM) were obtained at baseline and 6 months post-ADT. Central choroidal thickness (CCT) and ocular perfusion pressure (OPP) were also recorded.
[RESULTS] Serum testosterone significantly decreased (4.45 ± 1.96 to 0.20 ± 0.08 ng/mL; p < 0.001) after 6 months. Choroidal BOM increased significantly (0.94 ± 0.31 to 1.11 ± 0.31; p = 0.028), whereas CAVI (10.70 ± 1.28 to 10.68 ± 1.19), choroidal MBR (8.46 ± 4.50 to 7.89 ± 3.48), CCT, and OPP did not change significantly.
[CONCLUSION] Choroidal BOM increased significantly during the initial 6 months of ADT, indicating higher microvascular resistance despite stable choroidal blood flow and unchanged large artery stiffness. This supports a "microcirculation-first" model. LSFG-derived BOM may serve as a biomarker for early detection and monitoring of microcirculatory dysfunction under systemic testosterone suppression.
MeSH Terms
Humans; Male; Choroid; Microcirculation; Aged; Prostatic Neoplasms; Middle Aged; Androgen Antagonists; Testosterone; Laser-Doppler Flowmetry