Enhancing docetaxel efficacy in prostate cancer: the synergistic role of extract in inducing apoptosis and autophagy.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
varying concentrations of and DTX individually and in combination
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Additionally, AgNOR analysis indicated reduced proliferative capacity. These findings suggest that may enhance DTX efficacy and serve as a promising natural adjuvant in PC therapy.
Prostate cancer (PC) is a common malignancy in men, and resistance to treatment in advanced stages remains a significant clinical problem.
APA
Bitgen N, Onder GO, et al. (2026). Enhancing docetaxel efficacy in prostate cancer: the synergistic role of extract in inducing apoptosis and autophagy.. Toxicology research, 15(1), tfag004. https://doi.org/10.1093/toxres/tfag004
MLA
Bitgen N, et al.. "Enhancing docetaxel efficacy in prostate cancer: the synergistic role of extract in inducing apoptosis and autophagy.." Toxicology research, vol. 15, no. 1, 2026, pp. tfag004.
PMID
41623590 ↗
Abstract 한글 요약
Prostate cancer (PC) is a common malignancy in men, and resistance to treatment in advanced stages remains a significant clinical problem. Docetaxel (DTX) is widely used in advanced PC therapy; however, its efficacy can be limited by toxicity and acquired resistance. Therefore, plant-derived compounds are being explored as supportive therapeutic agents. This study investigated the cytotoxic and antiproliferative effects of () extract on PC-3 prostate cancer cells, both alone and in combination with DTX. PC-3 cells were treated with varying concentrations of and DTX individually and in combination. Cell viability was measured using the MTT assay, and proliferative activity was assessed by AgNOR staining. Cell cycle distribution was analyzed using a Muse cell analyzer, apoptosis was detected via the TUNEL assay, and autophagy-associated protein expression (LC3 and p62) was examined immunohistochemically. extract exhibited dose-dependent cytotoxicity with an IC of 8 μg/mL. The combined treatment with and DTX resulted in greater inhibition of cell viability, significant G0/G1 cell cycle arrest, increased apoptosis, and enhanced autophagy. Additionally, AgNOR analysis indicated reduced proliferative capacity. These findings suggest that may enhance DTX efficacy and serve as a promising natural adjuvant in PC therapy.
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