Severe exfoliative dermatitis induced by apalutamide in a mHSPC patient: A case report.
[RATIONALE] Apalutamide is a generation androgen antagonist for the treatment of metastatic hormone sensitive prostate cancer and non-metastatic castration resistant prostate cancer.
APA
Chen H, Li T, et al. (2026). Severe exfoliative dermatitis induced by apalutamide in a mHSPC patient: A case report.. Medicine, 105(7), e47428. https://doi.org/10.1097/MD.0000000000047428
MLA
Chen H, et al.. "Severe exfoliative dermatitis induced by apalutamide in a mHSPC patient: A case report.." Medicine, vol. 105, no. 7, 2026, pp. e47428.
PMID
41686612
Abstract
[RATIONALE] Apalutamide is a generation androgen antagonist for the treatment of metastatic hormone sensitive prostate cancer and non-metastatic castration resistant prostate cancer. Skin adverse reactions caused by apalutamide are mostly rashes and maculopapules.
[PATIENT CONCERNS] There are a few reports about exfoliative dermatitis caused by apalutamide.
[DIAGNOSES] Severe exfoliative dermatitis induced by apalutamide.
[INTERVENTIONS] Gamma globulin, cefoperazone sulbactam sodium, albumin, ebastine, loratadine, hydrocortisone cream, and 3% boric acid lotion.
[OUTCOMES] Whole-body skin was red, without exudation, and with a small amount of desquamation.
[LESSONS] The incidence of exfoliative dermatitis due to apalutamide is low but severe, and if a serious adverse skin reaction is suspected, apalutamide needs to be discontinued immediately and treated accordingly.
[PATIENT CONCERNS] There are a few reports about exfoliative dermatitis caused by apalutamide.
[DIAGNOSES] Severe exfoliative dermatitis induced by apalutamide.
[INTERVENTIONS] Gamma globulin, cefoperazone sulbactam sodium, albumin, ebastine, loratadine, hydrocortisone cream, and 3% boric acid lotion.
[OUTCOMES] Whole-body skin was red, without exudation, and with a small amount of desquamation.
[LESSONS] The incidence of exfoliative dermatitis due to apalutamide is low but severe, and if a serious adverse skin reaction is suspected, apalutamide needs to be discontinued immediately and treated accordingly.
MeSH Terms
Humans; Male; Thiohydantoins; Dermatitis, Exfoliative; Prostatic Neoplasms, Castration-Resistant; Aged
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