Patient awareness and perspectives regarding the value of focal therapy for localized prostate cancer: A cross-sectional study.

[BACKGROUND] With the expanding therapeutic options for localized prostate cancer (PCa), little is known regarding patient values and perspectives that influence the selection process for focal therapy (FT) vs. conventional treatments. This study explores the socioeconomic and demographic factors that influence patients' decisions for FT.

[METHODS] This was a single-center cross-sectional study using a patient-centered survey of men with concerns about or a diagnosis of localized prostate cancer who were potential candidates for focal therapy. Information on patient demographics and clinical status was collected along with hypothetical scenarios to study the preferences of patients. Descriptives and univariate tests of associations were utilized for analysis.

[RESULTS] In total, 158 patients were enrolled; only 41.1% of patients had prior knowledge of FT. Among those with a diagnosis of PCa and endorsing prior FT knowledge, 44.3% did not understand its efficacy, while 27.9% did not know if FT has any potential side effects. Education and income significantly influenced FT knowledge. Specifically, 52.4% of patients with advanced education were familiar with FT compared to 20% of those with only a high school education (P < 0.01). Patients with income of >$75,000 were more likely to be aware of FT (60.7%, P = 0.010). Interestingly, neither disease stability nor treatment status influenced therapy preferences. Sexually active patients were more likely to be aware of FT as an option.

[CONCLUSIONS] A considerable proportion of PCa patients, specifically those in lower socioeconomic groups, remain unaware of FT's existence and its potential role in well-selected PCa management. Educated and higher-income patients had comparatively better knowledge about FT and also leaned towards functional outcomes. As FT demand continues to expand, addressing knowledge gaps is crucial to ensure informed and equitable healthcare delivery.