Diagnostic Value of Multiparametric Transrectal Ultrasound in Patients with Suspected Carcinoma of Prostate: A Tertiary Care Centre Experience.
[OBJECTIVES] To establish the role of grayscale ultrasonography, shear wave elastography (SWE), and contrast-enhanced ultrasound (CEUS) independently and in combination with multiparametric transrecta
APA
Chowhan PS, Gorsi U, et al. (2026). Diagnostic Value of Multiparametric Transrectal Ultrasound in Patients with Suspected Carcinoma of Prostate: A Tertiary Care Centre Experience.. The Indian journal of radiology & imaging, 36(2), 175-182. https://doi.org/10.1055/s-0045-1809318
MLA
Chowhan PS, et al.. "Diagnostic Value of Multiparametric Transrectal Ultrasound in Patients with Suspected Carcinoma of Prostate: A Tertiary Care Centre Experience.." The Indian journal of radiology & imaging, vol. 36, no. 2, 2026, pp. 175-182.
PMID
41867289
Abstract
[OBJECTIVES] To establish the role of grayscale ultrasonography, shear wave elastography (SWE), and contrast-enhanced ultrasound (CEUS) independently and in combination with multiparametric transrectal ultrasound (mp-TRUS) in detecting peripheral zone prostate cancer (PCa) and to compare the performance of mp-TRUS with multiparametric MRI (mp-MRI), keeping biopsy as the gold standard.
[MATERIALS AND METHODS] Thirty men with clinically suspected PCa were enrolled in this single-center-based prospective study conducted over a period of 1.5 years. All patients underwent mp-MRI, mp-TRUS, and guided biopsy. The mp-MRI and mp-TRUS were conducted and interpreted by two different observers who were blinded to each other's findings. In all patients, biopsy cores were taken from a minimum of 12 predetermined sites with extra cores taken from lesions suspicious on either grayscale ultrasonography, SWE, or CEUS.
[RESULTS] Malignancy was detected in 19 of our patients on mp-TRUS-guided biopsy. A total of 386 cores were obtained with a positive biopsy rate of 38%. mp-TRUS gave a sensitivity, specificity, PPV, NPV, and diagnostic accuracy of 100, 63.63, 82.61, 100, and 86.67%, respectively, while the values for mp-MRI were 94.74, 45.45, 75.00, 83.33, and 76.67%, respectively. The area under the ROC curve for mp-TRUS was 0.818 ± 0.076. This value was higher than that for mp-MRI (0.701 ± 0.083).
[CONCLUSION] Performance of mp-TRUS is comparable to that of mp-MRI in diagnosing peripheral zone PCa. By improving the diagnostic yield of grayscale ultrasonography, mp-TRUS also acts as a great guiding tool for targeted biopsies, especially in patients where no lesions are seen on grayscale imaging.
[MATERIALS AND METHODS] Thirty men with clinically suspected PCa were enrolled in this single-center-based prospective study conducted over a period of 1.5 years. All patients underwent mp-MRI, mp-TRUS, and guided biopsy. The mp-MRI and mp-TRUS were conducted and interpreted by two different observers who were blinded to each other's findings. In all patients, biopsy cores were taken from a minimum of 12 predetermined sites with extra cores taken from lesions suspicious on either grayscale ultrasonography, SWE, or CEUS.
[RESULTS] Malignancy was detected in 19 of our patients on mp-TRUS-guided biopsy. A total of 386 cores were obtained with a positive biopsy rate of 38%. mp-TRUS gave a sensitivity, specificity, PPV, NPV, and diagnostic accuracy of 100, 63.63, 82.61, 100, and 86.67%, respectively, while the values for mp-MRI were 94.74, 45.45, 75.00, 83.33, and 76.67%, respectively. The area under the ROC curve for mp-TRUS was 0.818 ± 0.076. This value was higher than that for mp-MRI (0.701 ± 0.083).
[CONCLUSION] Performance of mp-TRUS is comparable to that of mp-MRI in diagnosing peripheral zone PCa. By improving the diagnostic yield of grayscale ultrasonography, mp-TRUS also acts as a great guiding tool for targeted biopsies, especially in patients where no lesions are seen on grayscale imaging.