Trans-cytolemmal water exchange in prostate manifest via DCE-MRI.
2/5 보강
OpenAlex 토픽 ·
MRI in cancer diagnosis
Prostate Cancer Diagnosis and Treatment
Lanthanide and Transition Metal Complexes
[OBJECTIVE] To investigate the potential of the unidirectional cellular water efflux rate constant (k) from DCE-MRI data in prostate MR imaging.
APA
Xin Li, Ryan Kopp, et al. (2026). Trans-cytolemmal water exchange in prostate manifest via DCE-MRI.. Magma (New York, N.Y.). https://doi.org/10.1007/s10334-026-01345-8
MLA
Xin Li, et al.. "Trans-cytolemmal water exchange in prostate manifest via DCE-MRI.." Magma (New York, N.Y.), 2026.
PMID
41984327
Abstract
[OBJECTIVE] To investigate the potential of the unidirectional cellular water efflux rate constant (k) from DCE-MRI data in prostate MR imaging.
[MATERIALS AND METHODS] High-temporal-resolution prostate DCE-MRI data were modeled using both the fast-exchange-limit (FXL) Tofts' model as well as the water-exchange-sensitized shutter-speed model (SSM). In the SSM, k was included as an additional fitting parameter. Lesion and normal-appearing (NA) prostate tissue region-of-interest (ROI) data were analyzed and categorized into FXL or non-FXL conditions based on results from the two models. A global upper limit of k detectable by prostate DCE-MRI with the SSM was presented.
[RESULTS] While many lesion voxels exhibited sensitivity to k with the SSM, a substantial portion remained in the FXL condition despite greater contrast agent extravasation than in NA tissue. The fraction of FXL voxels was higher in lesions than in NA tissue. Applying a global detectable k upper limit increased the difference between lesion and NA ROIs, improving lesion characterization.
[DISCUSSION] SSM-derived FXL and non-FXL contrasts may serve as novel imaging biomarkers for prostate cancer surveillance. Advances in MRI technology and more potent contrast agents are expected to enhance the accuracy of k quantification, potentially enabling its integration into clinical mpMRI.
[MATERIALS AND METHODS] High-temporal-resolution prostate DCE-MRI data were modeled using both the fast-exchange-limit (FXL) Tofts' model as well as the water-exchange-sensitized shutter-speed model (SSM). In the SSM, k was included as an additional fitting parameter. Lesion and normal-appearing (NA) prostate tissue region-of-interest (ROI) data were analyzed and categorized into FXL or non-FXL conditions based on results from the two models. A global upper limit of k detectable by prostate DCE-MRI with the SSM was presented.
[RESULTS] While many lesion voxels exhibited sensitivity to k with the SSM, a substantial portion remained in the FXL condition despite greater contrast agent extravasation than in NA tissue. The fraction of FXL voxels was higher in lesions than in NA tissue. Applying a global detectable k upper limit increased the difference between lesion and NA ROIs, improving lesion characterization.
[DISCUSSION] SSM-derived FXL and non-FXL contrasts may serve as novel imaging biomarkers for prostate cancer surveillance. Advances in MRI technology and more potent contrast agents are expected to enhance the accuracy of k quantification, potentially enabling its integration into clinical mpMRI.
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