Trends and Patterns in Prostate Cancer Diagnostics During the Era of MRI Implementation - Real-world Evidence From a Population-based Study in the Stockholm Region, Sweden 2010-2023.
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OpenAlex 토픽 ·
Prostate Cancer Diagnosis and Treatment
MRI in cancer diagnosis
Prostate Cancer Treatment and Research
[BACKGROUND AND OBJECTIVE] Pre-biopsy magnetic resonance imaging (MRI) is recommended in prostate cancer diagnostics, but its impact on testing patterns and diagnostic outcomes on a population-level r
- 95% CI 1.99-2.27
- RR 2.12
APA
Jan Chandra Engel, Balram Rai, et al. (2026). Trends and Patterns in Prostate Cancer Diagnostics During the Era of MRI Implementation - Real-world Evidence From a Population-based Study in the Stockholm Region, Sweden 2010-2023.. European urology open science, 87, 48-56. https://doi.org/10.1016/j.euros.2026.03.015
MLA
Jan Chandra Engel, et al.. "Trends and Patterns in Prostate Cancer Diagnostics During the Era of MRI Implementation - Real-world Evidence From a Population-based Study in the Stockholm Region, Sweden 2010-2023.." European urology open science, vol. 87, 2026, pp. 48-56.
PMID
42004833 ↗
Abstract 한글 요약
[BACKGROUND AND OBJECTIVE] Pre-biopsy magnetic resonance imaging (MRI) is recommended in prostate cancer diagnostics, but its impact on testing patterns and diagnostic outcomes on a population-level remains unclear.
[METHODS] Using the Stockholm Prostate Cancer Diagnostics Register, we conducted a population-based study of men aged ≥40 yr without prior prostate cancer during 2010-2023. We described the trends in prostate-specific antigen (PSA) testing, the proportion of men with PSA ≥3 ng/ml undergoing further testing (MRI and/or biopsy), and the distribution of biopsy outcomes.
[KEY FINDINGS AND LIMITATIONS] PSA testing was stable over time, with greater uptake observed in older men: in 2023, 14-yr prevalence was 76% in men aged 60-69 yr, and 84% in both those aged 70-79 and ≥80 yr. Among men with PSA ≥3 ng/ml, MRI within 1 yr increased from 3% in 2010 to 30% in 2023, while the proportion undergoing prostate biopsy declined from 23% to 16% (relative risk [RR]: 0.71; 95% confidence interval [CI]: 0.69-0.73). By 2023, 83% of biopsied men had a pre-biopsy MRI. Over the study period, biopsy outcomes improved: detection of International Society of Urological Pathology [ISUP] grade group [GG] ≥2 cancers more than doubled (RR: 2.12; 95% CI: 1.99-2.27), whereas both benign biopsies (RR: 0.66; 95% CI: 0.62-0.69) and ISUP GG 1 (RR: 0.61; 95% CI: 0.54-0.69) declined markedly.
[CONCLUSIONS AND CLINICAL IMPLICATIONS] PSA testing remained prevalent, and pre-biopsy MRI use increased substantially. During this period, detection of significant cancer among biopsied men increased markedly while unnecessary biopsies and low-grade cancer findings decreased. This study provides real-world population-based data that are consistent with a trend toward increased precision in prostate cancer diagnostics in the era of MRI implementation.
[METHODS] Using the Stockholm Prostate Cancer Diagnostics Register, we conducted a population-based study of men aged ≥40 yr without prior prostate cancer during 2010-2023. We described the trends in prostate-specific antigen (PSA) testing, the proportion of men with PSA ≥3 ng/ml undergoing further testing (MRI and/or biopsy), and the distribution of biopsy outcomes.
[KEY FINDINGS AND LIMITATIONS] PSA testing was stable over time, with greater uptake observed in older men: in 2023, 14-yr prevalence was 76% in men aged 60-69 yr, and 84% in both those aged 70-79 and ≥80 yr. Among men with PSA ≥3 ng/ml, MRI within 1 yr increased from 3% in 2010 to 30% in 2023, while the proportion undergoing prostate biopsy declined from 23% to 16% (relative risk [RR]: 0.71; 95% confidence interval [CI]: 0.69-0.73). By 2023, 83% of biopsied men had a pre-biopsy MRI. Over the study period, biopsy outcomes improved: detection of International Society of Urological Pathology [ISUP] grade group [GG] ≥2 cancers more than doubled (RR: 2.12; 95% CI: 1.99-2.27), whereas both benign biopsies (RR: 0.66; 95% CI: 0.62-0.69) and ISUP GG 1 (RR: 0.61; 95% CI: 0.54-0.69) declined markedly.
[CONCLUSIONS AND CLINICAL IMPLICATIONS] PSA testing remained prevalent, and pre-biopsy MRI use increased substantially. During this period, detection of significant cancer among biopsied men increased markedly while unnecessary biopsies and low-grade cancer findings decreased. This study provides real-world population-based data that are consistent with a trend toward increased precision in prostate cancer diagnostics in the era of MRI implementation.