Concordance of Detection Methods in Symptomatic Children and Adolescents.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
Histology with Giemsa staining is widely used in clinical settings due to its low cost and reliable performance.
I · Intervention 중재 / 시술
compared with expectations (PPA = 65
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Serology had the lowest performance (PPA = 53.7%, NPA = 96.1%, kappa = 0.548). [CONCLUSIONS] The combination of histology with Giemsa staining and RT-PCR achieved the highest detection rate and strongest agreement.
[BACKGROUND] is the most prevalent chronic bacterial infection globally, acquired mostly during childhood.
APA
Cabrera C, Campusano Y, et al. (2025). Concordance of Detection Methods in Symptomatic Children and Adolescents.. Microorganisms, 13(3). https://doi.org/10.3390/microorganisms13030583
MLA
Cabrera C, et al.. "Concordance of Detection Methods in Symptomatic Children and Adolescents.." Microorganisms, vol. 13, no. 3, 2025.
PMID
40142475 ↗
Abstract 한글 요약
[BACKGROUND] is the most prevalent chronic bacterial infection globally, acquired mostly during childhood. It is associated with chronic gastritis, peptic ulcer disease, and gastric cancer. Due to challenges in culturing , diagnostic reference standards often rely on combining ≥2 non-culture, biopsy-based methods. Histology with Giemsa staining is widely used in clinical settings due to its low cost and reliable performance.
[METHODS] This study evaluated the concordance between histology with Giemsa staining as the reference standard and other diagnostic methods, including the rapid urease test (RUT), ureA RT-PCR, 16S sequencing, and anti- serum IgG. Positive percent of agreement (PPA), negative percent of agreement (NPA) and concordance kappa index were calculated.
[RESULTS] A total of 120 patients (41 positive and 79 negative by Giemsa staining) were analyzed. Among the methods tested, RT-PCR for showed the best performance (PPA = 94.7%, NPA = 98.6%, kappa = 0.939), while RUT underperformed compared with expectations (PPA = 65.9%, NPA = 97.5%, kappa = 0.681). Serology had the lowest performance (PPA = 53.7%, NPA = 96.1%, kappa = 0.548).
[CONCLUSIONS] The combination of histology with Giemsa staining and RT-PCR achieved the highest detection rate and strongest agreement.
[METHODS] This study evaluated the concordance between histology with Giemsa staining as the reference standard and other diagnostic methods, including the rapid urease test (RUT), ureA RT-PCR, 16S sequencing, and anti- serum IgG. Positive percent of agreement (PPA), negative percent of agreement (NPA) and concordance kappa index were calculated.
[RESULTS] A total of 120 patients (41 positive and 79 negative by Giemsa staining) were analyzed. Among the methods tested, RT-PCR for showed the best performance (PPA = 94.7%, NPA = 98.6%, kappa = 0.939), while RUT underperformed compared with expectations (PPA = 65.9%, NPA = 97.5%, kappa = 0.681). Serology had the lowest performance (PPA = 53.7%, NPA = 96.1%, kappa = 0.548).
[CONCLUSIONS] The combination of histology with Giemsa staining and RT-PCR achieved the highest detection rate and strongest agreement.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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