Association of gene family and gene polymorphisms with gastric cancer risk in a Chinese population.
1/5 보강
[BACKGROUND] Gastric carcinogenesis is associated with defects in DNA damage repair pathways, in which the gene family (, , and ) play an important role in DNA repair.
- 95% CI 1.03-1.90
- OR 1.40
- HR 1.35
APA
Sun Y, Wang Y, et al. (2025). Association of gene family and gene polymorphisms with gastric cancer risk in a Chinese population.. Personalized medicine, 22(2), 103-111. https://doi.org/10.1080/17410541.2025.2473306
MLA
Sun Y, et al.. "Association of gene family and gene polymorphisms with gastric cancer risk in a Chinese population.." Personalized medicine, vol. 22, no. 2, 2025, pp. 103-111.
PMID
40059436 ↗
Abstract 한글 요약
[BACKGROUND] Gastric carcinogenesis is associated with defects in DNA damage repair pathways, in which the gene family (, , and ) play an important role in DNA repair. It is also well known that the gene, as a tumor suppressor, influences the development of gastric cancer.
[METHODS] We recruited 484 gastric cancer patients and 471 controls. DNA genotyping and infection were determined by commercial kits. Association between polymorphisms and gastric cancer risk and survival was evaluated through SPSS 26.0.
[RESULTS] Stratified analysis revealed that rs25487 TC/TT was associated with increased gastric cancer risk in the following four subgroups of males (adjusted OR = 1.40, 95% CI: 1.03-1.90, = 0.031), positive (adjusted OR = 1.58, 95% CI: 1.09-2.28, = 0.015), tumor stage III-IV (adjusted OR = 1.42, 95% CI: 1.06-1.89, = 0.017), and non-gastric cardiac adenocarcinoma (adjusted OR = 1.36, 95% CI: 1.02-1.82, = 0.034). Additionally, survival analysis indicated that rs25487 TC/TT genotype (HR = 1.35, 95% CI: 1.08-1.69, = 0.010) was associated with unfavorable survival in gastric cancer patients.
[CONCLUSION] rs25487 CC genotype decreased the risk of gastric cancer, and predicted a favorable survival prognosis.
[METHODS] We recruited 484 gastric cancer patients and 471 controls. DNA genotyping and infection were determined by commercial kits. Association between polymorphisms and gastric cancer risk and survival was evaluated through SPSS 26.0.
[RESULTS] Stratified analysis revealed that rs25487 TC/TT was associated with increased gastric cancer risk in the following four subgroups of males (adjusted OR = 1.40, 95% CI: 1.03-1.90, = 0.031), positive (adjusted OR = 1.58, 95% CI: 1.09-2.28, = 0.015), tumor stage III-IV (adjusted OR = 1.42, 95% CI: 1.06-1.89, = 0.017), and non-gastric cardiac adenocarcinoma (adjusted OR = 1.36, 95% CI: 1.02-1.82, = 0.034). Additionally, survival analysis indicated that rs25487 TC/TT genotype (HR = 1.35, 95% CI: 1.08-1.69, = 0.010) was associated with unfavorable survival in gastric cancer patients.
[CONCLUSION] rs25487 CC genotype decreased the risk of gastric cancer, and predicted a favorable survival prognosis.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Stomach Neoplasms
- Male
- Female
- Middle Aged
- X-ray Repair Cross Complementing Protein 1
- Cadherins
- Genetic Predisposition to Disease
- Polymorphism
- Single Nucleotide
- Antigens
- CD
- Aged
- DNA-Binding Proteins
- Risk Factors
- Genotype
- Helicobacter Infections
- China
- DNA Repair
- Helicobacter pylori
- Case-Control Studies
- Ku Autoantigen
- Adult
- East Asian People
… 외 5개
같은 제1저자의 인용 많은 논문 (5)
- Construction of hollow double shell NiMn PBA nanozymes for sensitive sarcosine detection a cascade strategy.
- Polydopamine-modified cyclodextrin metal-organic framework for efficient BCL-2 siRNA delivery in lung cancer therapy.
- Nuclear phosphoinositide signaling in cell biology and disease.
- CircNF1 promotes gastric cancer metastasis by stabilizing HMGA2 mRNA through IGF2BP1 interaction.
- Shaping a pro-carcinogenic hepatic microenvironment by TCDD: An integrated approach combining network toxicology, machine learning, molecular docking, molecular dynamics and experimental validation.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.