Prognostic value of c-MET protein expression in gastric cancer patients: a systematic review and meta-analysis.
메타분석
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
Subgroup analysis of OS revealed conflicting conclusions based on study design, cutoff values, and c-MET assays.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] High c-MET expression may independently predict poor GC prognosis. Future efforts should focus on standardized detection methods and high-quality prospective studies to validate its prognostic value.
[BACKGROUND] The heterogeneous nature of c-MET overexpression in gastric cancer (GC) leads to a lack of consensus on its prognostic significance.
- HR 1.39
- 연구 설계 systematic review
APA
Yang Q, Han X (2025). Prognostic value of c-MET protein expression in gastric cancer patients: a systematic review and meta-analysis.. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 30(5), 353-362. https://doi.org/10.1080/1354750X.2025.2544556
MLA
Yang Q, et al.. "Prognostic value of c-MET protein expression in gastric cancer patients: a systematic review and meta-analysis.." Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, vol. 30, no. 5, 2025, pp. 353-362.
PMID
40765181 ↗
Abstract 한글 요약
[BACKGROUND] The heterogeneous nature of c-MET overexpression in gastric cancer (GC) leads to a lack of consensus on its prognostic significance.
[OBJECTIVE] To evaluate the predictive value of c-MET protein expression in gastric cancer patients.
[METHODS] A systematic review of studies from PubMed, Web of Science, Embase, and Cochrane Library up to April 2025. Heterogeneity and robustness were assessed using the Cochrane Q test, I statistic, and sensitivity analysis. Publication bias was evaluated with Egger's and Begg's tests. The Newcastle-Ottawa Scale (NOS) assessed methodological quality.
[RESULTS] From 2,322 articles, 22 studies were included. High c-MET expression was significantly associated with reduced overall survival (OS) (Hazard Ratio [HR] = 1.22; 95% Confidence Interval [CI]: 1.13, 1.31; I = 6.8%; P = 0.371) and disease-free survival (DFS) (pooled HR = 1.39; 95% CI: 1.11, 1.68; I = 42.4%; P = 0.139). Definitions of c-MET positivity varied across studies regarding thresholds, staining intensity, and detection methods. Subgroup analysis of OS revealed conflicting conclusions based on study design, cutoff values, and c-MET assays.
[CONCLUSION] High c-MET expression may independently predict poor GC prognosis. Future efforts should focus on standardized detection methods and high-quality prospective studies to validate its prognostic value.
[OBJECTIVE] To evaluate the predictive value of c-MET protein expression in gastric cancer patients.
[METHODS] A systematic review of studies from PubMed, Web of Science, Embase, and Cochrane Library up to April 2025. Heterogeneity and robustness were assessed using the Cochrane Q test, I statistic, and sensitivity analysis. Publication bias was evaluated with Egger's and Begg's tests. The Newcastle-Ottawa Scale (NOS) assessed methodological quality.
[RESULTS] From 2,322 articles, 22 studies were included. High c-MET expression was significantly associated with reduced overall survival (OS) (Hazard Ratio [HR] = 1.22; 95% Confidence Interval [CI]: 1.13, 1.31; I = 6.8%; P = 0.371) and disease-free survival (DFS) (pooled HR = 1.39; 95% CI: 1.11, 1.68; I = 42.4%; P = 0.139). Definitions of c-MET positivity varied across studies regarding thresholds, staining intensity, and detection methods. Subgroup analysis of OS revealed conflicting conclusions based on study design, cutoff values, and c-MET assays.
[CONCLUSION] High c-MET expression may independently predict poor GC prognosis. Future efforts should focus on standardized detection methods and high-quality prospective studies to validate its prognostic value.
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