Gastric cancer risk and BRCA1/2 mutations: a systematic review and meta-analysis.
메타분석
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
551 patients were included, of whom 25,934 had BRCA1/2 mutations (BRCA1: 14322; BRCA2: 11612).
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Among the gastric cancer patients, BRCA1 and BRCA2 mutations were associated with RRs of 3.02 ( = 0.101; I = 65%) and 4.86 ( < 0.001; I = 0%), respectively. [CONCLUSIONS] This meta-analysis suggests that BRCA1/2 mutation carriers have a higher risk of developing gastric cancer.
[BACKGROUND] Gastric cancer is an aggressive and heterogeneous disease, primarily sporadic, with only 1-3% of cases being hereditary.
- 95% CI 1.33-3.97
- 연구 설계 meta-analysis
APA
de Moraes FCA, Matheus GTFU, et al. (2025). Gastric cancer risk and BRCA1/2 mutations: a systematic review and meta-analysis.. Personalized medicine, 22(4), 245-256. https://doi.org/10.1080/17410541.2025.2531737
MLA
de Moraes FCA, et al.. "Gastric cancer risk and BRCA1/2 mutations: a systematic review and meta-analysis.." Personalized medicine, vol. 22, no. 4, 2025, pp. 245-256.
PMID
40653790 ↗
Abstract 한글 요약
[BACKGROUND] Gastric cancer is an aggressive and heterogeneous disease, primarily sporadic, with only 1-3% of cases being hereditary. However, gastric cancer is a component of several hereditary cancer syndromes. The BRCA1 and BRCA2 genes encode key DNA repair proteins involved in homologous recombination. Studies suggest a significantly increased risk of gastric cancer in first-degree relatives of BRCA1/2 mutation carriers.
[METHODS] We systematically searched PubMed, Scopus, and Web of Science for relevant studies. Risk ratios (RRs) with 95% confidence intervals (CIs) were computed using DerSimonian and Laird random-effect models. Heterogeneity was assessed via I statistics. Statistical analyses were performed using R (version 4.2.3).
[RESULTS] Fourteen studies with 160,551 patients were included, of whom 25,934 had BRCA1/2 mutations (BRCA1: 14322; BRCA2: 11612). BRCA1 and BRCA2 mutations were significantly associated with increased gastric cancer risk (RR 2.30; 95% CI: 1.33-3.97; = 0.003; I = 82% and RR 2.45; 95% CI: 1.82-3.28; < 0.001; I = 25%). Among the gastric cancer patients, BRCA1 and BRCA2 mutations were associated with RRs of 3.02 ( = 0.101; I = 65%) and 4.86 ( < 0.001; I = 0%), respectively.
[CONCLUSIONS] This meta-analysis suggests that BRCA1/2 mutation carriers have a higher risk of developing gastric cancer.
[METHODS] We systematically searched PubMed, Scopus, and Web of Science for relevant studies. Risk ratios (RRs) with 95% confidence intervals (CIs) were computed using DerSimonian and Laird random-effect models. Heterogeneity was assessed via I statistics. Statistical analyses were performed using R (version 4.2.3).
[RESULTS] Fourteen studies with 160,551 patients were included, of whom 25,934 had BRCA1/2 mutations (BRCA1: 14322; BRCA2: 11612). BRCA1 and BRCA2 mutations were significantly associated with increased gastric cancer risk (RR 2.30; 95% CI: 1.33-3.97; = 0.003; I = 82% and RR 2.45; 95% CI: 1.82-3.28; < 0.001; I = 25%). Among the gastric cancer patients, BRCA1 and BRCA2 mutations were associated with RRs of 3.02 ( = 0.101; I = 65%) and 4.86 ( < 0.001; I = 0%), respectively.
[CONCLUSIONS] This meta-analysis suggests that BRCA1/2 mutation carriers have a higher risk of developing gastric cancer.
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