Neoadjuvant PD-1/PD-L1 inhibitors combined with chemotherapy in gastric cancer and gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis of single-arm studies.
메타분석
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
428 patients were included.
I · Intervention 중재 / 시술
surgical intervention, with 88 achieving pCR
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
However, limitations such as small sample sizes and insufficient follow-up duration in current studies highlight the need for further randomized controlled trials and multicenter research to establish optimal treatment strategies. [SYSTAMATIC REVIEW REGISTRATION] Identifier, CRD42024619916.
[BACKGROUND] Neoadjuvant chemotherapy, particularly neoadjuvant immunotherapy, has achieved significant progress in treating gastric cancer (GC) and gastroesophageal junction (GEJ) adenocarcinoma.
- 연구 설계 meta-analysis
APA
Leng J, Liu M, et al. (2025). Neoadjuvant PD-1/PD-L1 inhibitors combined with chemotherapy in gastric cancer and gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis of single-arm studies.. Frontiers in medicine, 12, 1625259. https://doi.org/10.3389/fmed.2025.1625259
MLA
Leng J, et al.. "Neoadjuvant PD-1/PD-L1 inhibitors combined with chemotherapy in gastric cancer and gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis of single-arm studies.." Frontiers in medicine, vol. 12, 2025, pp. 1625259.
PMID
40837578
Abstract
[BACKGROUND] Neoadjuvant chemotherapy, particularly neoadjuvant immunotherapy, has achieved significant progress in treating gastric cancer (GC) and gastroesophageal junction (GEJ) adenocarcinoma. While PD-1/PD-L1 inhibitors have improved survival outcomes in some patients, the efficacy of combining neoadjuvant chemotherapy with PD-1/PD-L1 inhibitors remains insufficiently validated.
[OBJECTIVE] This study aims to evaluate the efficacy and safety of neoadjuvant chemotherapy combined with PD-1/PD-L1 inhibitors in GC/GEJ adenocarcinoma and enhance statistical power through meta-analysis.
[METHODS] We systematically searched PubMed, Embase, Web of Science, and the Cochrane Library up to October 5, 2024, for original clinical studies on neoadjuvant PD-1/PD-L1 inhibitors combined with chemotherapy for GC/GEJ adenocarcinoma. Eligible studies were evaluated using the Methodological Index for Non-Randomized Studies (MINORS) Criteria. Meta-analysis was performed using R 4.4.2 software.
[RESULTS] A total of 12 studies involving 428 patients were included. The primary efficacy outcomes were pathological complete response (pCR) and major pathological response (MPR), while secondary outcomes included disease control rate (DCR) and the rate of lymph node downstaging to ypN0. The effect size (ES) for pCR was 20.94% [95% CI: 0.1698; 0.2518], and for MPR, the ES was 55.86% [95% CI: 0.4891; 0.6271]. Safety was evaluated using the incidence of grade ≥3 treatment-related adverse events (trAEs), immune-related adverse events (irAEs), postoperative complications, and R0 resection rate. The meta-analysis revealed that 406 patients underwent surgical intervention, with 88 achieving pCR. The pooled effect size for R0 resection rate was 95.2% [95% CI: 0.896; 0.989]. The ES values for grade ≥3 adverse events, immune-related adverse events, and postoperative complications were 0.54 [95% CI: 0.30; 0.77], 0.17 [95% CI: 0.07; 0.31], and 0.28 [95% CI: 0.15; 0.44], respectively.
[CONCLUSION] Neoadjuvant PD-1/PD-L1 inhibitor-based chemotherapy demonstrates promising therapeutic efficacy and safety in patients with gastric and gastroesophageal junction (GEJ) cancer. However, limitations such as small sample sizes and insufficient follow-up duration in current studies highlight the need for further randomized controlled trials and multicenter research to establish optimal treatment strategies.
[SYSTAMATIC REVIEW REGISTRATION] Identifier, CRD42024619916.
[OBJECTIVE] This study aims to evaluate the efficacy and safety of neoadjuvant chemotherapy combined with PD-1/PD-L1 inhibitors in GC/GEJ adenocarcinoma and enhance statistical power through meta-analysis.
[METHODS] We systematically searched PubMed, Embase, Web of Science, and the Cochrane Library up to October 5, 2024, for original clinical studies on neoadjuvant PD-1/PD-L1 inhibitors combined with chemotherapy for GC/GEJ adenocarcinoma. Eligible studies were evaluated using the Methodological Index for Non-Randomized Studies (MINORS) Criteria. Meta-analysis was performed using R 4.4.2 software.
[RESULTS] A total of 12 studies involving 428 patients were included. The primary efficacy outcomes were pathological complete response (pCR) and major pathological response (MPR), while secondary outcomes included disease control rate (DCR) and the rate of lymph node downstaging to ypN0. The effect size (ES) for pCR was 20.94% [95% CI: 0.1698; 0.2518], and for MPR, the ES was 55.86% [95% CI: 0.4891; 0.6271]. Safety was evaluated using the incidence of grade ≥3 treatment-related adverse events (trAEs), immune-related adverse events (irAEs), postoperative complications, and R0 resection rate. The meta-analysis revealed that 406 patients underwent surgical intervention, with 88 achieving pCR. The pooled effect size for R0 resection rate was 95.2% [95% CI: 0.896; 0.989]. The ES values for grade ≥3 adverse events, immune-related adverse events, and postoperative complications were 0.54 [95% CI: 0.30; 0.77], 0.17 [95% CI: 0.07; 0.31], and 0.28 [95% CI: 0.15; 0.44], respectively.
[CONCLUSION] Neoadjuvant PD-1/PD-L1 inhibitor-based chemotherapy demonstrates promising therapeutic efficacy and safety in patients with gastric and gastroesophageal junction (GEJ) cancer. However, limitations such as small sample sizes and insufficient follow-up duration in current studies highlight the need for further randomized controlled trials and multicenter research to establish optimal treatment strategies.
[SYSTAMATIC REVIEW REGISTRATION] Identifier, CRD42024619916.