Usefulness of [F]FAPI-04 and [F]FDG PET/CT for the Detection of Peritoneal Carcinomatosis: A Comparative Study.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
71 patients with suspected peritoneal malignancies were enrolled in our study.
I · Intervention 중재 / 시술
both [F]FAPI-04 and [F]FDG PET/CT imaging within 7 days
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] [F]FAPI-04 PET/CT outperformed [F]FDG PET/CT in the evaluation of peritoneal carcinomatosis, particularly in patients with gastric cancer. Furthermore, [F]FAPI-04 PET/CT may be used for the assessment of peritoneal carcinomatosis in patients, especially FAPI-PCI.
[RATIONALE AND OBJECTIVES] In this study, we aimed to compared the performance of [F]FAPI-04 and [F]fluorodeoxyglucose (FDG) positron emission tomography/computer tomography (PET/CT) in the evaluation
- p-value p=0.003
- p-value p<0.001
- Sensitivity 92.50%
APA
Jiang C, Zheng K, et al. (2025). Usefulness of [F]FAPI-04 and [F]FDG PET/CT for the Detection of Peritoneal Carcinomatosis: A Comparative Study.. Academic radiology, 32(10), 5897-5906. https://doi.org/10.1016/j.acra.2025.05.067
MLA
Jiang C, et al.. "Usefulness of [F]FAPI-04 and [F]FDG PET/CT for the Detection of Peritoneal Carcinomatosis: A Comparative Study.." Academic radiology, vol. 32, no. 10, 2025, pp. 5897-5906.
PMID
40541551 ↗
Abstract 한글 요약
[RATIONALE AND OBJECTIVES] In this study, we aimed to compared the performance of [F]FAPI-04 and [F]fluorodeoxyglucose (FDG) positron emission tomography/computer tomography (PET/CT) in the evaluation of peritoneal carcinomatosis.
[MATERIALS AND METHODS] 71 patients with suspected peritoneal malignancies were enrolled in our study. All the participants underwent both [F]FAPI-04 and [F]FDG PET/CT imaging within 7 days. The detection rates, diagnostic accuracies, semiquantitative parameters of the tracers, peritoneal cancer index (PCI) scores, and tumor markers were evaluated and compared.
[RESULTS] Among the 71 patients, 40 patients were diagnosed with peritoneal carcinomatosis, and 31 were true-negative patients. The sensitivity and accuracy of [F]FAPI-04 PET/CT were higher than those of [F]FDG PET/CT (sensitivity: 92.50% vs. 72.50%, p=0.003; accuracy: 91.55% vs. 80.28%, p<0.001), particularly in patients with gastric cancer. The SUVmax, tumor-to-liver background ratio (TBR-L), tumor-to-descending aorta ratio (TBR-A), and PCI score were significantly higher for [F]FAPI-04 PET/CT than [F]FDG PET/CT (all p<0.05). In the [F]FAPI-04 PET/CT group, the PCI score, TBR-L, TBR-A, TBR-M and SUVmax were higher in the high level group than the low level group (all p<0.05). The carbohydrate antigen 125 (CA 125) levels were strongly correlated with the PCI of both [F]FAPI-04 and [F]FDG PET/CT.
[CONCLUSION] [F]FAPI-04 PET/CT outperformed [F]FDG PET/CT in the evaluation of peritoneal carcinomatosis, particularly in patients with gastric cancer. Furthermore, [F]FAPI-04 PET/CT may be used for the assessment of peritoneal carcinomatosis in patients, especially FAPI-PCI.
[MATERIALS AND METHODS] 71 patients with suspected peritoneal malignancies were enrolled in our study. All the participants underwent both [F]FAPI-04 and [F]FDG PET/CT imaging within 7 days. The detection rates, diagnostic accuracies, semiquantitative parameters of the tracers, peritoneal cancer index (PCI) scores, and tumor markers were evaluated and compared.
[RESULTS] Among the 71 patients, 40 patients were diagnosed with peritoneal carcinomatosis, and 31 were true-negative patients. The sensitivity and accuracy of [F]FAPI-04 PET/CT were higher than those of [F]FDG PET/CT (sensitivity: 92.50% vs. 72.50%, p=0.003; accuracy: 91.55% vs. 80.28%, p<0.001), particularly in patients with gastric cancer. The SUVmax, tumor-to-liver background ratio (TBR-L), tumor-to-descending aorta ratio (TBR-A), and PCI score were significantly higher for [F]FAPI-04 PET/CT than [F]FDG PET/CT (all p<0.05). In the [F]FAPI-04 PET/CT group, the PCI score, TBR-L, TBR-A, TBR-M and SUVmax were higher in the high level group than the low level group (all p<0.05). The carbohydrate antigen 125 (CA 125) levels were strongly correlated with the PCI of both [F]FAPI-04 and [F]FDG PET/CT.
[CONCLUSION] [F]FAPI-04 PET/CT outperformed [F]FDG PET/CT in the evaluation of peritoneal carcinomatosis, particularly in patients with gastric cancer. Furthermore, [F]FAPI-04 PET/CT may be used for the assessment of peritoneal carcinomatosis in patients, especially FAPI-PCI.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- Long Term Results of Proton Therapy in Adult Infradiaphragmatic Lymphoma.
- Metabolic Trojan Horse: Multivalent Glucose Ligand Modified Near-Infrared-Absorbing Gold Nanorods for Targeted Photothermal Therapy.
- Integrated Weighted Gene Co-Expression Network and Single-Cell RNA Sequencing Analyses Reveal the Prognostic Significance of Hypoxia in Gastric Cancer.
- Interpretable multimodal PET/CT-EHR fusion via mixture-of-experts for prognostic stratification in mantle cell lymphoma: a multicenter study.
- Optimizing Mediastinal Lymph Node Dissection by Integrating Tumour Location, Consolidation Tumour Ratio, and Size for Lung Cancer.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Comprehensive analysis of androgen receptor splice variant target gene expression in prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.