HLA-G expression in peritumoral fundic gland mucous neck cells, but not in tumor lesions, related to poor survival in patients with gastric cancer.
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PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
283 case-matched peritumoral tissues (PTTs) was analyzed by immunohistochemistry.
I · Intervention 중재 / 시술
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C · Comparison 대조 / 비교
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O · Outcome 결과 / 결론
The fundic gland mucous neck cells were the only subpopulation that expressed HLA-G. [DISCUSSION] Our findings, for the first time, suggest that fundic gland mucous neck cell HLA-G expression in PTTs is associated with GC progression.
[INTRODUCTION] The concept that human leukocyte antigen-G (HLA-G) expression is specifically in various malignant lesions but absent in adjacent normal tissues has been well documented, and HLA-G is a
APA
Zhang X, Han QY, et al. (2025). HLA-G expression in peritumoral fundic gland mucous neck cells, but not in tumor lesions, related to poor survival in patients with gastric cancer.. Frontiers in immunology, 16, 1660054. https://doi.org/10.3389/fimmu.2025.1660054
MLA
Zhang X, et al.. "HLA-G expression in peritumoral fundic gland mucous neck cells, but not in tumor lesions, related to poor survival in patients with gastric cancer.." Frontiers in immunology, vol. 16, 2025, pp. 1660054.
PMID
41181133 ↗
Abstract 한글 요약
[INTRODUCTION] The concept that human leukocyte antigen-G (HLA-G) expression is specifically in various malignant lesions but absent in adjacent normal tissues has been well documented, and HLA-G is acknowledged as a novel immune checkpoint.
[METHODS] In this study, HLA-G expression in 523 gastric cancer (GC) lesions and 283 case-matched peritumoral tissues (PTTs) was analyzed by immunohistochemistry. The clinical significance of HLA-G expression in GC lesions and case-matched PTTs was evaluated, and a specific HLA-G-positive subpopulation in PTTs was identified.
[RESULTS] Data showed that HLA-G expression was significantly different between GC lesions (370/523, 70.7%) and PTTs (238/283, 84.1%; <0.001). HLA-G in GC lesions was more frequently observed in older patients (76.2% vs. 65.3%, =0.006), and HLA-G in PTTs was more commonly observed in female patients (92.0% vs. 80.5%, =0.014). Survival analysis revealed that HLA-G expression in PTTs (overall survival: 42.0 months vs. 56.7 months, =0.023), but not in GC lesions (52.1 months vs. 50.9 months, =0.623), is significantly associated with poor prognosis. The fundic gland mucous neck cells were the only subpopulation that expressed HLA-G.
[DISCUSSION] Our findings, for the first time, suggest that fundic gland mucous neck cell HLA-G expression in PTTs is associated with GC progression.
[METHODS] In this study, HLA-G expression in 523 gastric cancer (GC) lesions and 283 case-matched peritumoral tissues (PTTs) was analyzed by immunohistochemistry. The clinical significance of HLA-G expression in GC lesions and case-matched PTTs was evaluated, and a specific HLA-G-positive subpopulation in PTTs was identified.
[RESULTS] Data showed that HLA-G expression was significantly different between GC lesions (370/523, 70.7%) and PTTs (238/283, 84.1%; <0.001). HLA-G in GC lesions was more frequently observed in older patients (76.2% vs. 65.3%, =0.006), and HLA-G in PTTs was more commonly observed in female patients (92.0% vs. 80.5%, =0.014). Survival analysis revealed that HLA-G expression in PTTs (overall survival: 42.0 months vs. 56.7 months, =0.023), but not in GC lesions (52.1 months vs. 50.9 months, =0.623), is significantly associated with poor prognosis. The fundic gland mucous neck cells were the only subpopulation that expressed HLA-G.
[DISCUSSION] Our findings, for the first time, suggest that fundic gland mucous neck cell HLA-G expression in PTTs is associated with GC progression.
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