Prognostic model construction and mechanism analysis of ribosome biogenesis-related genes in gastric cancer based on WGCNA and machine learning methods.
1/5 보강
Ribosome biogenesis (RB) is crucial for cell proliferation, but the role of RB-related genes (RBRGs) in gastric cancer remains unclear.
APA
Zhang L, Li X, Feng Y (2025). Prognostic model construction and mechanism analysis of ribosome biogenesis-related genes in gastric cancer based on WGCNA and machine learning methods.. Computer methods in biomechanics and biomedical engineering, 1-17. https://doi.org/10.1080/10255842.2025.2579786
MLA
Zhang L, et al.. "Prognostic model construction and mechanism analysis of ribosome biogenesis-related genes in gastric cancer based on WGCNA and machine learning methods.." Computer methods in biomechanics and biomedical engineering, 2025, pp. 1-17.
PMID
41185412 ↗
Abstract 한글 요약
Ribosome biogenesis (RB) is crucial for cell proliferation, but the role of RB-related genes (RBRGs) in gastric cancer remains unclear. Using TCGA and GEO data, we identified differentially expressed RBRGs and constructed a robust 7-gene prognostic model. High-risk patients exhibited activated oncogenic pathways, suppressed cell cycle/DNA repair, enriched M2 macrophages and Tregs, and increased sensitivity to various antitumor drugs. This RBRG-based model effectively predicts gastric cancer prognosis and reveals subtype-specific biological and immune characteristics.
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