IGF Pathway Components as Potential Biomarkers in Gastric Cancer.
1/5 보강
Gastric cancer is one of the leading causes of cancer-related deaths worldwide, and due to its late-stage diagnosis, the prognosis is poor.
APA
Ceylaner B, Sahin F, et al. (2025). IGF Pathway Components as Potential Biomarkers in Gastric Cancer.. International journal of molecular sciences, 26(22). https://doi.org/10.3390/ijms262210880
MLA
Ceylaner B, et al.. "IGF Pathway Components as Potential Biomarkers in Gastric Cancer.." International journal of molecular sciences, vol. 26, no. 22, 2025.
PMID
41303367 ↗
Abstract 한글 요약
Gastric cancer is one of the leading causes of cancer-related deaths worldwide, and due to its late-stage diagnosis, the prognosis is poor. Therefore, researching biomarkers that can be used in early diagnosis and prognostic processes is crucial. Insulin-like growth factor (IGF) signaling pathways play critical roles in cellular proliferation, apoptosis, differentiation, and tumor progression. This study investigated the biomarker potential of IGF-1, IGFBP-4, IGFBP-5, and PAPP-A in gastric cancer. Forty gastric cancer patients and forty healthy individuals were included, and protein levels in serum samples were measured using the ELISA method. The findings showed that IGF-1 levels were significantly decreased in the gastric cancer group, while IGFBP-4 levels were significantly increased. IGFBP-5 levels were also lower in gastric cancer patients. In contrast, PAPP-A levels did not differ significantly between the two groups. ROC analyses revealed that IGF-1, IGFBP-4, and IGFBP-5 have good discriminatory properties in the diagnosis of gastric cancer, while PAPP-A offers low diagnostic value. In conclusion, this study suggests that IGF pathway components, particularly IGF-1, IGFBP-4, and IGFBP-5, might be promising biomarker candidates for gastric cancer.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Stomach Neoplasms
- Biomarkers
- Tumor
- Male
- Female
- Middle Aged
- Insulin-Like Growth Factor I
- Pregnancy-Associated Plasma Protein-A
- Insulin-Like Growth Factor Binding Protein 5
- Signal Transduction
- Insulin-Like Growth Factor Binding Protein 4
- Aged
- ROC Curve
- Adult
- Case-Control Studies
- IGF signaling
- biomarker
- gastric cancer
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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