Clinical and histological characteristics of gastric "crawling-type" adenocarcinoma.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
17 patients with histologically confirmed CTA.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] CTA is a histologically indolent but diagnostically challenging subtype of early gastric cancer. Recognition of its endoscopic and pathological features is essential for accurate diagnosis and management.
[BACKGROUND] Crawling-type adenocarcinoma (CTA) is an uncommon and poorly characterised subtype of early gastric cancer, primarily reported in isolated case and series studies.
APA
Zhang B, Gao W, et al. (2025). Clinical and histological characteristics of gastric "crawling-type" adenocarcinoma.. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 57(12), 2457-2463. https://doi.org/10.1016/j.dld.2025.09.017
MLA
Zhang B, et al.. "Clinical and histological characteristics of gastric "crawling-type" adenocarcinoma.." Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 57, no. 12, 2025, pp. 2457-2463.
PMID
41047289
Abstract
[BACKGROUND] Crawling-type adenocarcinoma (CTA) is an uncommon and poorly characterised subtype of early gastric cancer, primarily reported in isolated case and series studies.
[AIMS] To investigate the clinicopathological and endoscopic features of CTA.
[METHODS] We retrospectively analysed 17 patients with histologically confirmed CTA. Clinical characteristics, endoscopic findings, including magnifying endoscopy with narrow-band imaging (ME-NBI) and computed tomography (CT) imaging, were evaluated. Histological features were assessed using hematoxylin-eosin (H&E) staining, and immunohistochemistry was performed to study the clinical features.
[RESULT] The mean age was 68.7 years; 64.7 % were male. Most patients were asymptomatic. Endoscopically, CTA appeared as flat or slightly elevated lesions with indistinct margins and brownish discolouration. ME-NBI revealed dilated, tortuous microvessels and mild microsurface irregularity, while CT showed no metastasis. Histologically, 82.4 % of tumors were confined to the mucosa, consisting of moderately differentiated tubular glands with horizontal spread, mild to moderate atypia, and preserved polarity. Characteristic "shaking-hand" or "WHY × " patterns were observed. Immunohistochemically, cytokeratin was positive in all cases. MUC5AC and MUC6 were aberrantly expressed in 70.6 % of cases, and most showed p53 overexpression.
[CONCLUSION] CTA is a histologically indolent but diagnostically challenging subtype of early gastric cancer. Recognition of its endoscopic and pathological features is essential for accurate diagnosis and management.
[AIMS] To investigate the clinicopathological and endoscopic features of CTA.
[METHODS] We retrospectively analysed 17 patients with histologically confirmed CTA. Clinical characteristics, endoscopic findings, including magnifying endoscopy with narrow-band imaging (ME-NBI) and computed tomography (CT) imaging, were evaluated. Histological features were assessed using hematoxylin-eosin (H&E) staining, and immunohistochemistry was performed to study the clinical features.
[RESULT] The mean age was 68.7 years; 64.7 % were male. Most patients were asymptomatic. Endoscopically, CTA appeared as flat or slightly elevated lesions with indistinct margins and brownish discolouration. ME-NBI revealed dilated, tortuous microvessels and mild microsurface irregularity, while CT showed no metastasis. Histologically, 82.4 % of tumors were confined to the mucosa, consisting of moderately differentiated tubular glands with horizontal spread, mild to moderate atypia, and preserved polarity. Characteristic "shaking-hand" or "WHY × " patterns were observed. Immunohistochemically, cytokeratin was positive in all cases. MUC5AC and MUC6 were aberrantly expressed in 70.6 % of cases, and most showed p53 overexpression.
[CONCLUSION] CTA is a histologically indolent but diagnostically challenging subtype of early gastric cancer. Recognition of its endoscopic and pathological features is essential for accurate diagnosis and management.
MeSH Terms
Humans; Male; Stomach Neoplasms; Aged; Female; Retrospective Studies; Adenocarcinoma; Middle Aged; Tomography, X-Ray Computed; Immunohistochemistry; Narrow Band Imaging; Aged, 80 and over; Gastroscopy; Gastric Mucosa
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