Clinical Considerations of Splenic Dose Constraints to Mitigate Radiation-Induced Lymphopenia.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
159 patients were enrolled.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
It is important not only to prevent severe lymphopenia during RT but also to focus on improving lymphocyte recovery after RT. Constraining the spleen V is a key approach.
[BACKGROUND] The spleen dose-volume threshold for lymphopenia in abdominal radiotherapy has not yet reached a consensus.
APA
Ma Y, Zhang S, et al. (2026). Clinical Considerations of Splenic Dose Constraints to Mitigate Radiation-Induced Lymphopenia.. Cancer medicine, 15(1), e71553. https://doi.org/10.1002/cam4.71553
MLA
Ma Y, et al.. "Clinical Considerations of Splenic Dose Constraints to Mitigate Radiation-Induced Lymphopenia.." Cancer medicine, vol. 15, no. 1, 2026, pp. e71553.
PMID
41568450 ↗
Abstract 한글 요약
[BACKGROUND] The spleen dose-volume threshold for lymphopenia in abdominal radiotherapy has not yet reached a consensus. Our previous research indicated a correlation between these factors, but the threshold has not been determined. Therefore, we investigated the dynamic changes in lymphocytes during radiotherapy (RT), identified the spleen dose threshold, and examined how these factors affect patient prognosis.
[METHODS] The absolute lymphocyte counts (ALC) of gastric cancer patients were collected before, during, and after RT. Lymphocyte recovery status was assessed using the lymphocyte recovery index (LRI). LRI cut off was considered as insufficient recovery. Splenic dosimetric parameters were collected, and their impact on predicting grade 4 (G4) lymphopenia was evaluated using logistic regression analysis. Cox regression analysis was used to evaluate the relationship between lymphocyte depletion and recovery status and prognosis.
[RESULTS] 159 patients were enrolled. The median ALC dropped by 85.71% after RT. The occurrence of G4 and G1-3 lymphopenia was observed in 30.2% and 69.8% of cases, respectively. There were 12.6% of patients whose ALC had recovered at 120 days after RT, while the remaining 87.4% were still accompanied by lymphopenia. Cox multivariable analysis showed that pTNM stage and LRI were independent prognostic factors affecting overall survival, and the independent prognostic factors for disease-free survival were pTNM stage and change in ALC. Splenic D and V were related to G4 lymphopenia and eventually V affected prognosis. Constraining the spleen V to < 180.6 cm and < 272.2 cm may reduce the incidence of G4 lymphopenia and further decrease the risk of death by 60.9%.
[CONCLUSIONS] Patients with severe lymphocyte decline during RT and insufficient lymphocyte recovery afterward have a worse prognosis. It is important not only to prevent severe lymphopenia during RT but also to focus on improving lymphocyte recovery after RT. Constraining the spleen V is a key approach.
[METHODS] The absolute lymphocyte counts (ALC) of gastric cancer patients were collected before, during, and after RT. Lymphocyte recovery status was assessed using the lymphocyte recovery index (LRI). LRI cut off was considered as insufficient recovery. Splenic dosimetric parameters were collected, and their impact on predicting grade 4 (G4) lymphopenia was evaluated using logistic regression analysis. Cox regression analysis was used to evaluate the relationship between lymphocyte depletion and recovery status and prognosis.
[RESULTS] 159 patients were enrolled. The median ALC dropped by 85.71% after RT. The occurrence of G4 and G1-3 lymphopenia was observed in 30.2% and 69.8% of cases, respectively. There were 12.6% of patients whose ALC had recovered at 120 days after RT, while the remaining 87.4% were still accompanied by lymphopenia. Cox multivariable analysis showed that pTNM stage and LRI were independent prognostic factors affecting overall survival, and the independent prognostic factors for disease-free survival were pTNM stage and change in ALC. Splenic D and V were related to G4 lymphopenia and eventually V affected prognosis. Constraining the spleen V to < 180.6 cm and < 272.2 cm may reduce the incidence of G4 lymphopenia and further decrease the risk of death by 60.9%.
[CONCLUSIONS] Patients with severe lymphocyte decline during RT and insufficient lymphocyte recovery afterward have a worse prognosis. It is important not only to prevent severe lymphopenia during RT but also to focus on improving lymphocyte recovery after RT. Constraining the spleen V is a key approach.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- A Streamlined Protocol for Developing a Clinicopathological Prediction Model for Patient Survival of Post-Resection of Pancreatic Cancer.
- Thermosensitive spray-gel oxaliplatin delivery system for antitumor efficacy and mechanistic study in a mouse subcutaneous xenograft model.
- LAP2α drives breast tumorigenesis by mitigating replication stress.
- Short-course high-dose cytarabine consolidation therapy before allogeneic hematopoietic stem cell transplantation improves 2-year relapse-free survival but not overall survival in patients with acute myeloid leukemia: a single-center retrospective study.
- ISX promotes tumor migration and invasion in lung cancer by upregulating COL1A1 .
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.