Longitudinal health-related quality of life profiles in esophageal cancer: insights from a nationwide prospective observational cohort study.
코호트
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
605 patients (mean age: 66.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Patients' sex, BMI, and surgery status may help identify those needing extra support. [IMPLICATIONS FOR CANCER SURVIVORS] Recognizing different HRQoL profiles can help manage recovery expectations, and guide more personalized and timely care after treatment.
[PURPOSE] Identifying patients with similar health-related quality of life (HRQoL) recovery patterns can guide more effective disease management.
- 연구 설계 cross-sectional
APA
Deuning-Smit E, Vos JAM, et al. (2026). Longitudinal health-related quality of life profiles in esophageal cancer: insights from a nationwide prospective observational cohort study.. Journal of cancer survivorship : research and practice. https://doi.org/10.1007/s11764-026-01968-9
MLA
Deuning-Smit E, et al.. "Longitudinal health-related quality of life profiles in esophageal cancer: insights from a nationwide prospective observational cohort study.." Journal of cancer survivorship : research and practice, 2026.
PMID
41555149 ↗
Abstract 한글 요약
[PURPOSE] Identifying patients with similar health-related quality of life (HRQoL) recovery patterns can guide more effective disease management. This study aimed to identify cross-sectional and longitudinal HRQoL profiles in esophageal cancer patients, and to examine associations with demographic and clinical characteristics.
[METHODS] Longitudinal data from the Prospective Observational Cohort Study of Esophageal-gastric cancer Patients (POCOP) were analyzed. Patients treated with chemoradiation (CRT), with/without surgery, were followed for 12 months post-treatment. HRQoL was measured pre-treatment, at 6- and 12-months using validated questionnaires (i.e., EORTC QLQ-C30, QLQ-OG25, and HADS). Latent Profile and Latent Transition analyses were used to identify cross-sectional and longitudinal profiles, respectively. Regression analyses explored their associations with demographic and clinical characteristics.
[RESULTS] Of the 605 patients (mean age: 66.6 (SD: 8.0) years), most were male (82%) and had undergone surgery (73%). At each time point, two cross-sectional HRQoL profiles were identified: one with relatively high HRQoL (78-84%) and low HRQoL (16-22%). Both profiles showed significant impairments compared to population norms. Longitudinal analyses revealed five distinct HRQoL profiles: stable-high (65%), stable-low (5%), improving (10%), deteriorating (14%), and fluctuating (6%). Poorer HRQoL was associated with female sex and lower body mass index. Fluctuating HRQoL with surgery.
[CONCLUSIONS] In our cohort, most esophageal cancer patients experienced relatively high or improving HRQoL, but some faced deteriorating or persistent impairments. Patients' sex, BMI, and surgery status may help identify those needing extra support.
[IMPLICATIONS FOR CANCER SURVIVORS] Recognizing different HRQoL profiles can help manage recovery expectations, and guide more personalized and timely care after treatment.
[METHODS] Longitudinal data from the Prospective Observational Cohort Study of Esophageal-gastric cancer Patients (POCOP) were analyzed. Patients treated with chemoradiation (CRT), with/without surgery, were followed for 12 months post-treatment. HRQoL was measured pre-treatment, at 6- and 12-months using validated questionnaires (i.e., EORTC QLQ-C30, QLQ-OG25, and HADS). Latent Profile and Latent Transition analyses were used to identify cross-sectional and longitudinal profiles, respectively. Regression analyses explored their associations with demographic and clinical characteristics.
[RESULTS] Of the 605 patients (mean age: 66.6 (SD: 8.0) years), most were male (82%) and had undergone surgery (73%). At each time point, two cross-sectional HRQoL profiles were identified: one with relatively high HRQoL (78-84%) and low HRQoL (16-22%). Both profiles showed significant impairments compared to population norms. Longitudinal analyses revealed five distinct HRQoL profiles: stable-high (65%), stable-low (5%), improving (10%), deteriorating (14%), and fluctuating (6%). Poorer HRQoL was associated with female sex and lower body mass index. Fluctuating HRQoL with surgery.
[CONCLUSIONS] In our cohort, most esophageal cancer patients experienced relatively high or improving HRQoL, but some faced deteriorating or persistent impairments. Patients' sex, BMI, and surgery status may help identify those needing extra support.
[IMPLICATIONS FOR CANCER SURVIVORS] Recognizing different HRQoL profiles can help manage recovery expectations, and guide more personalized and timely care after treatment.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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