ERAS pathway adherence and its association with return to intended oncological therapy after gastrectomy.
코호트
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
742 patients undergoing gastrectomy across 72 Spanish hospitals (2019-2020).
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] While ERAS pathways may aid recovery, their impact on RIOT depends on high adherence and is overshadowed by tumour-related factors. Future efforts should integrate ERAS with prehabilitation for high-risk patients and target adherence thresholds ≥70 %.
[BACKGROUND] Enhanced Recovery After Surgery (ERAS) pathways improve short-term outcomes in abdominal surgery, but their impact on timely initiation of adjuvant chemotherapy (Return to Intended Oncolo
- 95% CI 0.42-0.97
- 연구 설계 cohort study
APA
Bretscher AL, Melchor JR, et al. (2026). ERAS pathway adherence and its association with return to intended oncological therapy after gastrectomy.. Surgical oncology, 64, 102346. https://doi.org/10.1016/j.suronc.2025.102346
MLA
Bretscher AL, et al.. "ERAS pathway adherence and its association with return to intended oncological therapy after gastrectomy.." Surgical oncology, vol. 64, 2026, pp. 102346.
PMID
41478224 ↗
Abstract 한글 요약
[BACKGROUND] Enhanced Recovery After Surgery (ERAS) pathways improve short-term outcomes in abdominal surgery, but their impact on timely initiation of adjuvant chemotherapy (Return to Intended Oncologic Therapy, RIOT) in gastric cancer remains uncertain.
[METHODS] This multicenter, prospective cohort study (POWER4, NCT03865810) analysed 742 patients undergoing gastrectomy across 72 Spanish hospitals (2019-2020). ERAS adherence was assessed by quartiles.
[PRIMARY OUTCOME] timely RIOT (chemotherapy initiation ≤56 days post-surgery).
[SECONDARY OUTCOME] time to RIOT (days). Multivariable logistic and Cox regression models adjusted for clinical/tumour factors.
[RESULTS] Of 742 patients, 65 % achieved timely RIOT. Quartile-based univariable analysis revealed shorter time to RIOT with higher adherence (Q4 vs. Q1: HR 0.64, 95 % CI 0.42-0.97, *p* = 0.034), but this association disappeared in multivariable models. Advanced TNM stage (e.g.
[, IIIC] HR 18.6, *p* < 0.001) and ASA class were stronger predictors of delayed RIOT.
[CONCLUSIONS] While ERAS pathways may aid recovery, their impact on RIOT depends on high adherence and is overshadowed by tumour-related factors. Future efforts should integrate ERAS with prehabilitation for high-risk patients and target adherence thresholds ≥70 %.
[METHODS] This multicenter, prospective cohort study (POWER4, NCT03865810) analysed 742 patients undergoing gastrectomy across 72 Spanish hospitals (2019-2020). ERAS adherence was assessed by quartiles.
[PRIMARY OUTCOME] timely RIOT (chemotherapy initiation ≤56 days post-surgery).
[SECONDARY OUTCOME] time to RIOT (days). Multivariable logistic and Cox regression models adjusted for clinical/tumour factors.
[RESULTS] Of 742 patients, 65 % achieved timely RIOT. Quartile-based univariable analysis revealed shorter time to RIOT with higher adherence (Q4 vs. Q1: HR 0.64, 95 % CI 0.42-0.97, *p* = 0.034), but this association disappeared in multivariable models. Advanced TNM stage (e.g.
[, IIIC] HR 18.6, *p* < 0.001) and ASA class were stronger predictors of delayed RIOT.
[CONCLUSIONS] While ERAS pathways may aid recovery, their impact on RIOT depends on high adherence and is overshadowed by tumour-related factors. Future efforts should integrate ERAS with prehabilitation for high-risk patients and target adherence thresholds ≥70 %.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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