Genetic Susceptibility to Infection and Pancreatic Cancer Risk: A Two-Sample Mendelian Randomisation Study.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
936 cases, 400,294 controls) and a combined dataset including UK Biobank, FinnGen, and MVP (5979 cases, 1,234,860 controls).
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
: This 2SMR study found no evidence that infection causally increases pancreatic cancer risk. Larger studies with refined exposure measures are warranted.
: Pancreatic cancer is one of the most lethal malignancies, with poor survival and few established modifiable risk factors.
- 표본수 (n) 4638
- 95% CI 0.846-1.440
APA
Yang NY, Ke TM, et al. (2026). Genetic Susceptibility to Infection and Pancreatic Cancer Risk: A Two-Sample Mendelian Randomisation Study.. Life (Basel, Switzerland), 16(2). https://doi.org/10.3390/life16020284
MLA
Yang NY, et al.. "Genetic Susceptibility to Infection and Pancreatic Cancer Risk: A Two-Sample Mendelian Randomisation Study.." Life (Basel, Switzerland), vol. 16, no. 2, 2026.
PMID
41752920 ↗
Abstract 한글 요약
: Pancreatic cancer is one of the most lethal malignancies, with poor survival and few established modifiable risk factors. While () infection is a known cause of gastric cancer, its role in pancreatic cancer remains unclear, with inconsistent observational evidence. : We applied two-sample Mendelian randomisation (2SMR) to assess the causal effect of infection on pancreatic cancer risk. Genetic instruments were derived from GWAS data on anti- IgG levels in the ALSPAC cohort (n = 4638). Outcomes were pancreatic cancer cases from UK Biobank (936 cases, 400,294 controls) and a combined dataset including UK Biobank, FinnGen, and MVP (5979 cases, 1,234,860 controls). Inverse-variance weighted (IVW) MR was the primary method, supported by MR-Egger, weighted median/mode and MR-PRESSO, with sensitivity analyses for pleiotropy. : No significant causal association was observed. IVW ORs were 1.039 (95% CI: 0.846-1.440, = 0.466) for UK Biobank and 1.077 (95% CI: 0.962-1.206, = 0.197) for the combined dataset. All complementary methods yielded null results, with no strong evidence of pleiotropy. : This 2SMR study found no evidence that infection causally increases pancreatic cancer risk. Larger studies with refined exposure measures are warranted.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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