Beyond CoCl₂: Toward decision-grade hypoxia modeling in gastric cancer histobiology.
2/5 보강
OpenAlex 토픽 ·
Sphingolipid Metabolism and Signaling
Cancer, Hypoxia, and Metabolism
ATP Synthase and ATPases Research
Hypoxia is a characteristic, although heterogeneous, of solid tumors, and experimental hypoxia is still far too frequently addressed as a single replaceable phenomenon.
APA
Mulavagili Srikanth, Ajay Singh, M Vijayasimha (2026). Beyond CoCl₂: Toward decision-grade hypoxia modeling in gastric cancer histobiology.. Acta histochemica, 128(2), 152333. https://doi.org/10.1016/j.acthis.2026.152333
MLA
Mulavagili Srikanth, et al.. "Beyond CoCl₂: Toward decision-grade hypoxia modeling in gastric cancer histobiology.." Acta histochemica, vol. 128, no. 2, 2026, pp. 152333.
PMID
41931916 ↗
Abstract 한글 요약
Hypoxia is a characteristic, although heterogeneous, of solid tumors, and experimental hypoxia is still far too frequently addressed as a single replaceable phenomenon. Yashiro et al. demonstrate in their recent article in Acta Histochemica that the signaling of lysophosphatidic acid receptor in gastric cancer cells differs significantly in cobalt chloride-induced but not physiological hypoxia with resulting differences in motility and cisplatin response. It is not an observation merely at the receptor level but it reveals a deeper reproducibility and translational issue in tumor biology. Pathway attribution, interpretation of drug-response and prioritization of targets can be misleading when chemical hypoxia is to be used as a surrogate to oxygen deprivation without explicit validation. We believe that this paper must motivate the field-wide to abandon convenience-driven hypoxia modelling in favour of decision-grade hypoxia phenotyping. There should be future work to incorporate physiologically accurate oxygen control, orthogonal confirmation of hypoxic conditions, spatially resolved histochemical reporters and standard reporting of receptor-context interactions. This framework would enhance mechanistic accuracy, enhance cross-study comparability, and expedite translation of hypoxia-informed therapeutic interventions in gastric cancer and other diseases.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- Advances in Targeted Therapy for Human Epidermal Growth Factor Receptor 2-Low Tumors: From Trastuzumab to Antibody-Drug Conjugates.
- Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in -amplified gastric cancer.
- Association of preoperative frailty and prognostic nutritional index with postoperative delirium in elderly gastric cancer patients: A single-center observational study.
- Treating a single tumor deposits as two lymph node metastases can improve the accuracy of gastric cancer prognosis assessment.
- A case of pulmonary mucosa-associated lymphoid tissue lymphoma with plasmacytic differentiation and amyloid deposition: case report and literature review.
- Complete response to Nivolumab-based chemotherapy in a case of advanced gastric cancer with multiple immune-related adverse events.