Utility of Oesophagogastroduodenoscopy in Lynch Syndrome.
OpenAlex 토픽 ·
Genetic factors in colorectal cancer
Immunodeficiency and Autoimmune Disorders
Colorectal Cancer Screening and Detection
[GOAL] This study aims to investigate the outcomes in Lynch syndrome associated with routine second-yearly oesophagogastroduodenoscopy (OGD).
APA
Douglas Tjandra, Omar Salehi, et al. (2026). Utility of Oesophagogastroduodenoscopy in Lynch Syndrome.. Journal of clinical gastroenterology. https://doi.org/10.1097/MCG.0000000000002382
MLA
Douglas Tjandra, et al.. "Utility of Oesophagogastroduodenoscopy in Lynch Syndrome.." Journal of clinical gastroenterology, 2026.
PMID
42029141
Abstract
[GOAL] This study aims to investigate the outcomes in Lynch syndrome associated with routine second-yearly oesophagogastroduodenoscopy (OGD).
[BACKGROUND] The role of OGD for surveillance in Lynch syndrome remains contentious, with variation in guidelines. Our service runs a dedicated high-risk gastrointestinal risk management clinic where OGD is offered every second year after recruitment into surveillance.
[METHODS] Patients with Lynch syndrome who underwent at least one OGD were retrospectively reviewed. Demographics, clinical risk factors, personal and family history of malignancy, and endoscopic/histologic findings at OGD were evaluated. Logistic regression, Kaplan-Meier and Cox regression analysis were used to evaluate factors associated with premalignant and malignant lesions.
[RESULTS] A total of 296 patients were identified, with a total of 962 OGDs performed. Dysplasia was identified in 9 patients (3.0%), the majority of which were in the duodenum (66.7%). Two cases (0.7%) were diagnosed with duodenal adenocarcinoma. Premalignant lesions were seen in 20.9% (3.7% Barrett's metaplasia, 16.2% GIM, 1.0% both). Multivariable analysis did not identify predictors of dysplasia or malignancy. Tobacco smoking was associated with premalignant lesions at baseline and on follow-up.
[CONCLUSIONS] Our Lynch syndrome cohort demonstrated high rates of premalignant, dysplastic or malignant lesions (22.6%). High-risk lesions showed a predilection for the duodenum. This study suggests a role for routine OGD in patients with Lynch syndrome.
[BACKGROUND] The role of OGD for surveillance in Lynch syndrome remains contentious, with variation in guidelines. Our service runs a dedicated high-risk gastrointestinal risk management clinic where OGD is offered every second year after recruitment into surveillance.
[METHODS] Patients with Lynch syndrome who underwent at least one OGD were retrospectively reviewed. Demographics, clinical risk factors, personal and family history of malignancy, and endoscopic/histologic findings at OGD were evaluated. Logistic regression, Kaplan-Meier and Cox regression analysis were used to evaluate factors associated with premalignant and malignant lesions.
[RESULTS] A total of 296 patients were identified, with a total of 962 OGDs performed. Dysplasia was identified in 9 patients (3.0%), the majority of which were in the duodenum (66.7%). Two cases (0.7%) were diagnosed with duodenal adenocarcinoma. Premalignant lesions were seen in 20.9% (3.7% Barrett's metaplasia, 16.2% GIM, 1.0% both). Multivariable analysis did not identify predictors of dysplasia or malignancy. Tobacco smoking was associated with premalignant lesions at baseline and on follow-up.
[CONCLUSIONS] Our Lynch syndrome cohort demonstrated high rates of premalignant, dysplastic or malignant lesions (22.6%). High-risk lesions showed a predilection for the duodenum. This study suggests a role for routine OGD in patients with Lynch syndrome.