Causes of mortality among patients with early-stage hepatocellular carcinoma.
코호트
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
1336 patients with early-stage HCC, 598 (44.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] Cause of death varies among patients with early-stage HCC, although HCC-related death remains the most common cause. Efforts are needed to optimize curative treatment effectiveness among patients with early-stage HCC to reduce cancer-related mortality.
[BACKGROUND AND AIMS] Early detection of hepatocellular carcinoma (HCC) can reduce cancer-related mortality; however, there are often competing risks from comorbid conditions, including cirrhosis.
- 95% CI 22-31
- 추적기간 32.4 months
- 연구 설계 cohort study
APA
Seif El Dahan K, Daher D, et al. (2025). Causes of mortality among patients with early-stage hepatocellular carcinoma.. Hepatology (Baltimore, Md.). https://doi.org/10.1097/HEP.0000000000001471
MLA
Seif El Dahan K, et al.. "Causes of mortality among patients with early-stage hepatocellular carcinoma.." Hepatology (Baltimore, Md.), 2025.
PMID
40694813 ↗
Abstract 한글 요약
[BACKGROUND AND AIMS] Early detection of hepatocellular carcinoma (HCC) can reduce cancer-related mortality; however, there are often competing risks from comorbid conditions, including cirrhosis. Understanding causes of death among patients with early-stage HCC can inform strategies to improve surveillance effectiveness.
[APPROACH AND RESULTS] We conducted a retrospective cohort study of patients with early-stage HCC [Barcelona Clinic Liver Cancer (BCLC) stages 0/A] at 4 U.S. health systems between 2008 and 2022. We defined the primary cause of death as HCC-related, liver-related (non-HCC), and death from other causes. We used multivariable and Fine-Gray analysis, with liver transplant as a competing outcome, to identify factors associated with mortality. Among 1336 patients with early-stage HCC, 598 (44.8%) died during a median follow-up of 32.4 months-220 (37%) HCC-related, 114 (19%) liver-related, and 179 (30%) from other causes. Median time to death was similar between the groups: 24 (95% CI 22-31), 19 (95% CI 15-23), and 23 (95% CI 19-27) months for HCC-related, liver-related, and other causes of mortality, respectively. Curative treatment was associated with reduced HCC-related (HR 0.34; 95% CI 0.23-0.48) and liver-related mortality (HR 0.23; 95% CI 0.14-0.38). Predictors of HCC-related mortality included alpha-fetoprotein (AFP) >20 ng/mL (HR 2.19; 95% CI 1.59-3.03) and tumor diameter >3 cm (HR 1.69; 95% CI 1.20-2.37). Liver-related mortality was associated with MASLD (metabolic dysfunction-associated steatotic liver disease) etiology (HR 1.99; 95% CI 1.09-3.65), Child-Pugh B cirrhosis (HR 2.64; 95% CI 1.58-4.42), and Albumin-Bilirubin (ALBI) grade 2 (vs. grade 1: HR 2.47; 95% CI 1.21-5.06).
[CONCLUSIONS] Cause of death varies among patients with early-stage HCC, although HCC-related death remains the most common cause. Efforts are needed to optimize curative treatment effectiveness among patients with early-stage HCC to reduce cancer-related mortality.
[APPROACH AND RESULTS] We conducted a retrospective cohort study of patients with early-stage HCC [Barcelona Clinic Liver Cancer (BCLC) stages 0/A] at 4 U.S. health systems between 2008 and 2022. We defined the primary cause of death as HCC-related, liver-related (non-HCC), and death from other causes. We used multivariable and Fine-Gray analysis, with liver transplant as a competing outcome, to identify factors associated with mortality. Among 1336 patients with early-stage HCC, 598 (44.8%) died during a median follow-up of 32.4 months-220 (37%) HCC-related, 114 (19%) liver-related, and 179 (30%) from other causes. Median time to death was similar between the groups: 24 (95% CI 22-31), 19 (95% CI 15-23), and 23 (95% CI 19-27) months for HCC-related, liver-related, and other causes of mortality, respectively. Curative treatment was associated with reduced HCC-related (HR 0.34; 95% CI 0.23-0.48) and liver-related mortality (HR 0.23; 95% CI 0.14-0.38). Predictors of HCC-related mortality included alpha-fetoprotein (AFP) >20 ng/mL (HR 2.19; 95% CI 1.59-3.03) and tumor diameter >3 cm (HR 1.69; 95% CI 1.20-2.37). Liver-related mortality was associated with MASLD (metabolic dysfunction-associated steatotic liver disease) etiology (HR 1.99; 95% CI 1.09-3.65), Child-Pugh B cirrhosis (HR 2.64; 95% CI 1.58-4.42), and Albumin-Bilirubin (ALBI) grade 2 (vs. grade 1: HR 2.47; 95% CI 1.21-5.06).
[CONCLUSIONS] Cause of death varies among patients with early-stage HCC, although HCC-related death remains the most common cause. Efforts are needed to optimize curative treatment effectiveness among patients with early-stage HCC to reduce cancer-related mortality.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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