LINC-PINT: A Distinctive Long Non-Coding RNA Functioning as a Potential Suppressor in Tumorigenesis.

[INTRODUCTION] Long noncoding RNAs are essential regulators in numerous biological processes and have been linked to various diseases, including cancer. Despite their initial classification as transcriptional byproducts, lncRNAs have been shown to modulate chromatin structure, transcription, RNA processing, protein translation, and intranuclear transport. LINC-PINT, a lncRNA induced by P53, is particularly noteworthy for its role in tumor suppression across multiple cancers.

[METHODS] By utilizing the PubMed database and applying inclusion criteria based on relevance, literature quality, and data availability, we conducted a comprehensive analysis of 128 studies to provide an overview of the functions of LINC-PINT and its mechanisms of action in cancers.

[RESULTS] LINC-PINT was confirmed to function as a tumor suppressor factor in many cancers, such as triple-negative breast cancer, non-small cell lung cancer, gastric cancer, glioma, melanoma, osteosarcoma, laryngeal squamous cell carcinoma, esophageal cancer, colorectal cancer, nasopharyngeal carcinoma, retinoblastoma, ovarian cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer by promoting apoptosis and senescence, inhibiting proliferation, migration, invasion, drug resistance, cell stemness, EMT, radioresistance, and DNA damage repair.

[DISCUSSION] LINC-PINT serves as a tumor suppressor with its ability to sponge miRNAs, regulate epigenetic modulation, DNA damage repair, etc. Despite the promising findings, the complex and tissue-specific functions of LINC-PINT, along with the need for further clinical validation, underscore the importance of continued research to fully understand its mechanisms and potential as a therapeutic target.

[CONCLUSION] LINC-PINT is a potential target in cancer progression and treatment.