The value of acetylation reader YEATS2 in hepatocellular carcinoma management.
1/5 보강
Hepatocellular carcinoma (HCC) is frequently associated with Yeats-domain containing 2 (YEATS2) overexpression, which enhances tumor progression via the PI3K/AKT pathway.
APA
Shi Y, Xiao Q, et al. (2025). The value of acetylation reader YEATS2 in hepatocellular carcinoma management.. Scientific reports, 15(1), 27613. https://doi.org/10.1038/s41598-025-09945-5
MLA
Shi Y, et al.. "The value of acetylation reader YEATS2 in hepatocellular carcinoma management.." Scientific reports, vol. 15, no. 1, 2025, pp. 27613.
PMID
40731114 ↗
Abstract 한글 요약
Hepatocellular carcinoma (HCC) is frequently associated with Yeats-domain containing 2 (YEATS2) overexpression, which enhances tumor progression via the PI3K/AKT pathway. Our study delineates YEATS2's oncogenic functions in HCC and its potential as a prognostic and predictive biomarker. Through comprehensive in vitro and bioinformatics analyses, we reveal that YEATS2 promotes cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). Additionally, YEATS2 modulates the tumor immune microenvironment and predicts response to immunotherapies and chemotherapies. YEATS2's serum stability suggests its utility as a non-invasive biomarker for personalized HCC treatment.
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