A Genetic Twist: Cytologic Evaluation of Pancreatic Adenocarcinoma and Steatohepatitic Hepatocellular Carcinoma in a Patient With a Rare POLE Mutation.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
endoscopic ultrasound-guided fine-needle aspirations of a pancreatic head mass and a liver lesion
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Given her history of multiple malignancies, she underwent genetic testing, and a rare germline POLE mutation was discovered. This case expands the phenotypic spectrum of potential POLE-associated syndromes and highlights the critical role of cytopathology in fine-needle aspiration procedures for diagnosis and management of complex oncologic cases.
Mutations in the DNA polymerase epsilon (POLE) gene are associated with an increased risk of various malignancies, including colorectal and other gastrointestinal, endometrial, ovarian, breast, and br
APA
Messersmith L, Rizvi AH, et al. (2025). A Genetic Twist: Cytologic Evaluation of Pancreatic Adenocarcinoma and Steatohepatitic Hepatocellular Carcinoma in a Patient With a Rare POLE Mutation.. Diagnostic cytopathology, 53(8), E160-E164. https://doi.org/10.1002/dc.25488
MLA
Messersmith L, et al.. "A Genetic Twist: Cytologic Evaluation of Pancreatic Adenocarcinoma and Steatohepatitic Hepatocellular Carcinoma in a Patient With a Rare POLE Mutation.." Diagnostic cytopathology, vol. 53, no. 8, 2025, pp. E160-E164.
PMID
40396404 ↗
DOI
10.1002/dc.25488
Abstract 한글 요약
Mutations in the DNA polymerase epsilon (POLE) gene are associated with an increased risk of various malignancies, including colorectal and other gastrointestinal, endometrial, ovarian, breast, and brain cancers. In extremely rare cases, POLE mutations have also been associated with pancreatic and hepatobiliary carcinomas. We present the case of an 87-year-old female with a complex medical history including multiple malignancies, who underwent endoscopic ultrasound-guided fine-needle aspirations of a pancreatic head mass and a liver lesion. Utilizing rapid on-site evaluation (ROSE) and full cytologic workup, she was ultimately diagnosed with synchronous pancreatic adenocarcinoma and the steatohepatitic variant of hepatocellular carcinoma. Given her history of multiple malignancies, she underwent genetic testing, and a rare germline POLE mutation was discovered. This case expands the phenotypic spectrum of potential POLE-associated syndromes and highlights the critical role of cytopathology in fine-needle aspiration procedures for diagnosis and management of complex oncologic cases.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Female
- Pancreatic Neoplasms
- Liver Neoplasms
- Carcinoma
- Hepatocellular
- DNA Polymerase II
- Aged
- 80 and over
- Adenocarcinoma
- Poly-ADP-Ribose Binding Proteins
- Endoscopic Ultrasound-Guided Fine Needle Aspiration
- Mutation
- Neoplasms
- Multiple Primary
- POLE
- cytopathology
- fine‐needle aspiration
- hepatocellular carcinoma
- pancreatic adenocarcinoma
- tumor predisposition syndromes
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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