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Computational design and validation of small molecule inhibitors for type III phosphatidylinositol-4-kinase alpha, a hepatitis C drug target.

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Journal of biomolecular structure & dynamics 📖 저널 OA 1.8% 2023~2026 2025 Vol.43(14) p. 7934-7948

PICO 자동 추출 (휴리스틱, conf 2/4)

P · Population 대상 환자/모집단

환자: hepatitis C virus infection in the liver have been associated with increased levels of PI4P at the endoplasmic reticulum

I · Intervention 중재 / 시술

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C · Comparison 대조 / 비교

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O · Outcome 결과 / 결론

The findings of this work suggest that the selected small molecules may be used as lead molecules for the development of novel PI4KIIIα inhibitors. It is also anticipated that these thorough studies will be helpful in the structure-based drug design of PI4KIIIα inhibitors.

Pagag J, Andola P, Durgam L, Guruprasad L

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