Decoding the functional network of circular RNAs encoding proteins in hepatocellular carcinoma: from carcinogenesis to clinical transformation.
1/5 보강
[BACKGROUND] Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy with limited therapeutic options.
APA
Zheng J, He T, et al. (2025). Decoding the functional network of circular RNAs encoding proteins in hepatocellular carcinoma: from carcinogenesis to clinical transformation.. Journal of advanced research. https://doi.org/10.1016/j.jare.2025.09.017
MLA
Zheng J, et al.. "Decoding the functional network of circular RNAs encoding proteins in hepatocellular carcinoma: from carcinogenesis to clinical transformation.." Journal of advanced research, 2025.
PMID
40945848 ↗
Abstract 한글 요약
[BACKGROUND] Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy with limited therapeutic options. Circular RNAs (circRNAs) have emerged as key regulators in HCC. They influence oncogenic pathways by acting as microRNA (miRNA) sponges, protein interaction mediators, and exosomal messengers, and their protein-coding potential further boosts their functional importance in cancer progression.
[AIM OF REVIEW] This review aims to evaluate the roles of circRNA-encoded proteins in HCC metastasis, apoptosis, therapy resistance, and metabolic reprogramming. It also discusses the latest detection methods and RNA-based therapeutic strategies. KEY SCIENTIFIC CONCEPTS OF REVIEW: circRNAs-encoded proteins can modulate key cellular processes and serve as promising biomarkers and therapeutic targets. The review integrates findings across cancer types and emphasizes current challenges in delivery, detection sensitivity, and mechanistic elucidation. Tackling these issues will be essential for translating circRNA-derived proteins into precision medicine for HCC.
[AIM OF REVIEW] This review aims to evaluate the roles of circRNA-encoded proteins in HCC metastasis, apoptosis, therapy resistance, and metabolic reprogramming. It also discusses the latest detection methods and RNA-based therapeutic strategies. KEY SCIENTIFIC CONCEPTS OF REVIEW: circRNAs-encoded proteins can modulate key cellular processes and serve as promising biomarkers and therapeutic targets. The review integrates findings across cancer types and emphasizes current challenges in delivery, detection sensitivity, and mechanistic elucidation. Tackling these issues will be essential for translating circRNA-derived proteins into precision medicine for HCC.
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