Peri-operative management considerations for localised upper tract urothelial carcinoma in the setting of Lynch syndrome.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
neoadjuvant gemcitabine and split-dose cisplatin, leading to a complete pathological response, ypT0N0
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
An initial attempt to obtain an insurance approval for pembrolizumab given LS and context of deficient mismatch repair was unsuccessful. She subsequently received neoadjuvant gemcitabine and split-dose cisplatin, leading to a complete pathological response, ypT0N0.
Lynch syndrome (LS)-associated upper tract urothelial cancer (UTUC) is an overall rare malignancy comprising only 5%-10% of all urothelial carcinomas.
APA
Notardonato L, Wahab A, et al. (2025). Peri-operative management considerations for localised upper tract urothelial carcinoma in the setting of Lynch syndrome.. BMJ case reports, 18(9). https://doi.org/10.1136/bcr-2025-265380
MLA
Notardonato L, et al.. "Peri-operative management considerations for localised upper tract urothelial carcinoma in the setting of Lynch syndrome.." BMJ case reports, vol. 18, no. 9, 2025.
PMID
41033700 ↗
Abstract 한글 요약
Lynch syndrome (LS)-associated upper tract urothelial cancer (UTUC) is an overall rare malignancy comprising only 5%-10% of all urothelial carcinomas. Given its rarity, specific management guidelines for LS-associated UTUC do not exist. The optimal peri-operative management of localised LS-UTUC remains unknown, and with future approvals, immunotherapy may allow for organ preservation. This report describes a case of localised LS-UTUC with prior history of stage I colon cancer. An initial attempt to obtain an insurance approval for pembrolizumab given LS and context of deficient mismatch repair was unsuccessful. She subsequently received neoadjuvant gemcitabine and split-dose cisplatin, leading to a complete pathological response, ypT0N0.
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