Nephrotic syndrome after switching from irinotecan, S-1, and bevacizumab combination to trifluridine/tipiracil.
1/5 보강
Trifluridine/tipiracil (FTD/TPI) has shown efficacy in treating advanced colorectal and gastric cancers.
APA
Takami J, Nakano Y, et al. (2025). Nephrotic syndrome after switching from irinotecan, S-1, and bevacizumab combination to trifluridine/tipiracil.. CEN case reports, 14(5), 768-773. https://doi.org/10.1007/s13730-025-01014-0
MLA
Takami J, et al.. "Nephrotic syndrome after switching from irinotecan, S-1, and bevacizumab combination to trifluridine/tipiracil.." CEN case reports, vol. 14, no. 5, 2025, pp. 768-773.
PMID
40637925 ↗
Abstract 한글 요약
Trifluridine/tipiracil (FTD/TPI) has shown efficacy in treating advanced colorectal and gastric cancers. Although renal injury due to FTD/TPI is rare, its renal effects have not been well documented. We present the case of a 74-year-old man with metastatic colon cancer who developed nephrotic syndrome with hematuria after transitioning from a regimen of irinotecan, S-1, and bevacizumab to FTD/TPI. Renal biopsy revealed IgA nephropathy with glomerular microangiopathy (GMA). His condition improved with steroid therapy. To our knowledge, this is the first documented case of nephrotic syndrome associated with FTD/TPI. Renal toxicity should be monitored through urinalysis during FTD/TPI treatment.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Male
- Aged
- Drug Combinations
- Trifluridine
- Pyrrolidines
- Irinotecan
- Oxonic Acid
- Tegafur
- Bevacizumab
- Antineoplastic Combined Chemotherapy Protocols
- Thymine
- Nephrotic Syndrome
- Colonic Neoplasms
- Hematuria
- Glomerulonephritis
- IGA
- Kidney
- Glomerular microangiopathy
- IgA nephropathy
- Nephrotic syndrome
- Trifluridine/tipiracil
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.