METTL3 facilitates colorectal cancer growth through altering the abundance of intestinal Akkermansia muciniphila.
Colorectal cancer (CRC) is a prevalent malignant tumor that poses a significant threat to human health; however, the precise mechanism underlying its onset remains elusive.
APA
Wu L, Lian W, et al. (2025). METTL3 facilitates colorectal cancer growth through altering the abundance of intestinal Akkermansia muciniphila.. Cancer gene therapy, 32(10), 1098-1106. https://doi.org/10.1038/s41417-025-00949-x
MLA
Wu L, et al.. "METTL3 facilitates colorectal cancer growth through altering the abundance of intestinal Akkermansia muciniphila.." Cancer gene therapy, vol. 32, no. 10, 2025, pp. 1098-1106.
PMID
40790086
Abstract
Colorectal cancer (CRC) is a prevalent malignant tumor that poses a significant threat to human health; however, the precise mechanism underlying its onset remains elusive. In this study, we utilized metagenomic sequencing to reveal the dysregulation of intestinal microbiota caused by CRC. Single-cell sequencing data showed elevated mRNA expression of methyltransferase-like protein 3 (METTL3) in CRC, which was correlated with the abundance of intestinal microbiota. Furthermore, we found that METTL3 promotion of CRC progression is microbiota-dependent. Using induced METTL3 Vil1-cre mice, we identified the microbiota regulated by METTL3 in CRC. Our research indicates that METTL3 leads to high expression of HIF1α, which promotes the expression of lipocalin 2 (LCN2) in CRC cells, inhibiting the abundance of Akkermansia muciniphila, thereby promoting CRC progression.
MeSH Terms
Colorectal Neoplasms; Animals; Mice; Humans; Gastrointestinal Microbiome; Methyltransferases; Akkermansia; Cell Line, Tumor
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