Probiotic-based derived exopolysaccharide-zinc oxide nanoparticles: a novel approach to colorectal cancer gene modulation.
1/5 보강
The second deadliest cancer in the world is colorectal cancer (CRC), which is caused by the uncontrolled proliferation of epithelial cells in the colon.
APA
Afsharipoor S, Nazari R, et al. (2025). Probiotic-based derived exopolysaccharide-zinc oxide nanoparticles: a novel approach to colorectal cancer gene modulation.. Bioorganic chemistry, 165, 109025. https://doi.org/10.1016/j.bioorg.2025.109025
MLA
Afsharipoor S, et al.. "Probiotic-based derived exopolysaccharide-zinc oxide nanoparticles: a novel approach to colorectal cancer gene modulation.." Bioorganic chemistry, vol. 165, 2025, pp. 109025.
PMID
41037865 ↗
Abstract 한글 요약
The second deadliest cancer in the world is colorectal cancer (CRC), which is caused by the uncontrolled proliferation of epithelial cells in the colon. This research examines the role of key genes-including tumor suppressors ING4 and APC, angiogenesis-related DHX32, and the oncogenic mutated P53-in the SW480 cell line. Probiotics and their exopolysaccharide (EPS) component show potential in cancer prevention and treatment due to their antioxidant and anti-cancer properties. Zinc oxide nanoparticles (ZnONPs), recognized for their unique physical and chemical characteristics, have broad applications in drug delivery, cancer diagnostics, and therapy. In this project, EPS was extracted from Lactiplantibacillus plantarum and used for ZnONPs biosynthesis, followed by characterization through UV-VIS, XRD, FTIR, FE-SEM, and zeta potential analysis. Cytotoxic effects of EPS and ZnONPs were evaluated on SW480 cells, along with their antioxidant properties. Quantitative real-time PCR analysis revealed decreased expression of DHX32 and P53, while ING4 and APC gene expression increased following treatment of the cancerous cell line with target agents. These findings suggest that probiotic-derived EPS and ZnONPs may offer effective strategies for CRC treatment by modulating critical gene expression involved in disease progression.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Probiotics
- Colorectal Neoplasms
- Polysaccharides
- Bacterial
- Zinc Oxide
- Antineoplastic Agents
- Drug Screening Assays
- Antitumor
- Cell Proliferation
- Nanoparticles
- Structure-Activity Relationship
- Dose-Response Relationship
- Drug
- Cell Line
- Tumor
- Particle Size
- Molecular Structure
- Antioxidants
- Cell Survival
- Angiogenesis
- Colorectal cancer
- Exopolysaccharide
- Tumor suppressor and oncogenic genes
… 외 1개
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Comprehensive analysis of androgen receptor splice variant target gene expression in prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.