Unique dysregulation of miR-7, miR-15, and miR-203 as novel biomarkers in Egyptian colorectal cancer.
[BACKGROUND] Over the past decade, multiple research studies have focused on using miRNA expression in colorectal cancer (CRC) pathogenesis.
APA
Farouk S, Elbrashy MM, et al. (2025). Unique dysregulation of miR-7, miR-15, and miR-203 as novel biomarkers in Egyptian colorectal cancer.. Biomarkers in medicine, 19(20), 999-1008. https://doi.org/10.1080/17520363.2025.2585779
MLA
Farouk S, et al.. "Unique dysregulation of miR-7, miR-15, and miR-203 as novel biomarkers in Egyptian colorectal cancer.." Biomarkers in medicine, vol. 19, no. 20, 2025, pp. 999-1008.
PMID
41217222
Abstract
[BACKGROUND] Over the past decade, multiple research studies have focused on using miRNA expression in colorectal cancer (CRC) pathogenesis.
[MATERIALS & METHODS] 150 cases of two phases, where 14 miRNAs were first estimated in 75 cases for screening, followed by measuring miR-203a-3p, miR-7-5p, and miR-15b-5p relative expression in 75 subjects for further validation. Insilico analyses were done for confirmation.
[RESULTS] miR-203a-3p and miR-15b-5p were significantly downregulated, whereas miR-7-5p was highly expressed in CRC patients. Significantly elevated diagnostic efficacy for CRC was observed for miR-203a-3p, miR-7-5p, and miR-15b-5p ( < 0.001). Serum expression levels of these miRNAs are positively correlated with their matched tissue expression levels ( < 0.001).
[CONCLUSION] Diagnostic biomarker potential was identified for miR-203a-3p, miR-7-5p, and miR-15b-5p in CRC.
[MATERIALS & METHODS] 150 cases of two phases, where 14 miRNAs were first estimated in 75 cases for screening, followed by measuring miR-203a-3p, miR-7-5p, and miR-15b-5p relative expression in 75 subjects for further validation. Insilico analyses were done for confirmation.
[RESULTS] miR-203a-3p and miR-15b-5p were significantly downregulated, whereas miR-7-5p was highly expressed in CRC patients. Significantly elevated diagnostic efficacy for CRC was observed for miR-203a-3p, miR-7-5p, and miR-15b-5p ( < 0.001). Serum expression levels of these miRNAs are positively correlated with their matched tissue expression levels ( < 0.001).
[CONCLUSION] Diagnostic biomarker potential was identified for miR-203a-3p, miR-7-5p, and miR-15b-5p in CRC.
MeSH Terms
MicroRNAs; Colorectal Neoplasms; Egypt; Biomarkers, Tumor; Humans; Up-Regulation; Down-Regulation; Male; Female; Middle Aged